Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс:
http://elar.urfu.ru/handle/10995/89985
Название: | Inhibition of AT1 receptors by losartan affects myocardial slow force response in healthy but not in monocrotaline-treated young rats |
Авторы: | Lookin, O. Balakin, A. Protsenko, Y. |
Дата публикации: | 2018 |
Издатель: | Slovak Academy of Sciences |
Библиографическое описание: | Lookin, O. Inhibition of AT1 receptors by losartan affects myocardial slow force response in healthy but not in monocrotaline-treated young rats / O. Lookin, A. Balakin, Y. Protsenko. — DOI 10.4149/gpb_2017025 // General Physiology and Biophysics. — 2018. — Vol. 2. — Iss. 37. — P. 153-162. |
Аннотация: | The slow force response (SFR) of a cardiac muscle to a sudden stretch is thought to be important in the regulatory adaptation of myocardial contraction. Autocrine-paracrine regulation pathways which involve angiotensin II are participating in this mechanism. On the other hand, renin-angiotensin-aldosterone system (RAS) is altered in hypertrophic or failing myocardium. We compared the effects of sudden stretch to SFR as well as to twitch and Ca2+ transient characteristics in rat myocardium with monocrotaline-induced heart failure with those in normal rat myocardium without and with inhibition of angiotensin II type-1 (AT1) receptors. Our findings indicate that the myocardium of rats with monocrotaline-induced right ventricular failure is deficient with activation of local RAS and therefore expresses blunted SFR, very similar to the depression of SFR observed in normal myocardium under inhibition of AT1 receptors. The "failing" myocardium does not further respond to the "putative" inhibition of AT1 receptors by losartan. In conclusion, SFR is related to autocrine-paracrine regulation of myocardial contraction in normal rat myocardium and that the involvement of RAS into stretch-induced modulation of contractility may be significantly altered in failing heart. © 2018 Slovak Academy of Sciences. All rights reserved. |
Ключевые слова: | ANGIOTENSIN II TYPE-1 (AT1) RECEPTORS CA2+ TRANSIENT HYPERTROPHY/HEART FAILURE MONOCROTALINE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM SLOW FORCE RESPONSE ANGIOTENSIN 1 RECEPTOR CALCIUM ION LOSARTAN POTASSIUM MONOCROTALINE ANGIOTENSIN 1 RECEPTOR ANGIOTENSIN 1 RECEPTOR ANTAGONIST LOSARTAN MONOCROTALINE ANIMAL EXPERIMENT ANIMAL MODEL ANIMAL TISSUE ARTICLE CONTROLLED STUDY FEMALE HEART CONTRACTION HEART MUSCLE CONTRACTILE FORCE HEART MUSCLE CONTRACTILITY HEART RIGHT VENTRICLE FAILURE MALE MONOCROTALINE-INDUCED PULMONARY HYPERTENSION MUSCLE TWITCH NONHUMAN RAT RECEPTOR BLOCKING RENIN ANGIOTENSIN ALDOSTERONE SYSTEM SLOW FORCE RESPONSE ANIMAL CARDIAC MUSCLE CHEMICALLY INDUCED DRUG EFFECT HEART FAILURE METABOLISM PATHOPHYSIOLOGY PHYSIOLOGY WISTAR RAT ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS ANIMALS FEMALE HEART FAILURE LOSARTAN MALE MONOCROTALINE MYOCARDIAL CONTRACTION MYOCARDIUM RATS RATS, WISTAR RECEPTOR, ANGIOTENSIN, TYPE 1 RENIN-ANGIOTENSIN SYSTEM |
URI: | http://elar.urfu.ru/handle/10995/89985 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор РИНЦ: | 35542242 |
Идентификатор SCOPUS: | 85044996751 |
Идентификатор WOS: | 000429506600004 |
Идентификатор PURE: | 7031362 |
ISSN: | 0231-5882 |
DOI: | 10.4149/gpb_2017025 |
Сведения о поддержке: | Российский Фонд Фундаментальных Исследований (РФФИ): 16-04-00545 Ural Branch, Russian Academy of Sciences: 15-5-4-6 Division of Industrial Innovation and Partnerships Russian Academy of Sciences: A18-118020590031-8 Acknowledgements. Authors thank Daniil Kuznetsov for his help in the implementation of the monocrotaline-based experimental model of pulmonary hypertension in rats. The work was conducted in IIP UB RAS accordingly to the officially registered plan of scientific investigations (#AAAA-A18-118020590031-8) and was supported by Russian Foundation for Basic Research (grant #16-04-00545) and the Program for Basic Research of Ural Branch of the Russian Academy of Sciences for 2015–2017 (project #15-5-4-6). |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
---|---|---|---|---|
10.4149-gpb_2017025.pdf | 571,69 kB | Adobe PDF | Просмотреть/Открыть |
Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.