Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/75282
Title: Toxic effects of low-level long-term inhalation exposures of rats to nickel oxide nanoparticles
Authors: Sutunkova, M. P.
Solovyeva, S. N.
Minigalieva, I. A.
Gurvich, V. B.
Valamina, I. E.
Makeyev, O. H.
Shur, V. Y.
Shishkina, E. V.
Zubarev, I. V.
Saatkhudinova, R. R.
Klinova, S. V.
Tsaregorodtseva, A. E.
Korotkov, A. V.
Shuman, E. A.
Privalova, L. I.
Katsnelson, B. A.
Issue Date: 2019
Publisher: MDPI AG
Citation: Toxic effects of low-level long-term inhalation exposures of rats to nickel oxide nanoparticles / M. P. Sutunkova, S. N. Solovyeva, I. A. Minigalieva et al. // International Journal of Molecular Sciences. — 2019. — Vol. 20. — Iss. 7. — 1778.
Abstract: Rats were exposed to nickel oxide nanoparticles (NiO-NP) inhalation at 0.23 ± 0.01 mg/m3 for 4 h a day 5 times a week for up to 10 months. The rat organism responded to this impact with changes in cytological and some biochemical characteristics of the bronchoalveolar lavage fluid along with a paradoxically little pronounced pulmonary pathology associated with a rather low chronic retention of nanoparticles in the lungs. There were various manifestations of systemic toxicity, including damage to the liver and kidneys; a likely allergic syndrome as indicated by some cytological signs; transient stimulation of erythropoiesis; and penetration of nickel into the brain from the nasal mucous membrane along the olfactory pathway. Against a picture of mild to moderate chronic toxicity of nickel, its in vivo genotoxic effect assessed by the degree of DNA fragmentation in nucleated blood cells (the RAPD test) was pronounced, tending to increasing with the length of the exposure period. When rats were given orally, in parallel with the toxic exposure, a set of innocuous substances with differing mechanisms of expected bioprotective action, the genotoxic effect of NiO-NPs was found to be substantially attenuated. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: BIOPROTECTORS
GENOTOXICITY
INHALATION EXPOSURE
NICKEL OXIDE NANOPARTICLES
PULMONARY RESPONSES
SYSTEMIC TOXICITY
ALANINE AMINOTRANSFERASE
ALBUMIN
ALKALINE PHOSPHATASE
ASPARTATE AMINOTRANSFERASE
BILIRUBIN
CATALASE
CERULOPLASMIN
CREATININE
GAMMA GLUTAMYLTRANSFERASE
GENOMIC DNA
GLOBULIN
GLUTATHIONE
MALONALDEHYDE
NANOPARTICLE
NICKEL OXIDE NANOPARTICLE
SUCCINATE DEHYDROGENASE
UNCLASSIFIED DRUG
UREA
URIC ACID
AGAR GEL ELECTROPHORESIS
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMAL TISSUE
ARTICLE
BIOCHEMICAL ANALYSIS
BODY WEIGHT CHANGE
BRONCHOALVEOLAR LAVAGE FLUID
CONTROLLED STUDY
DNA FRAGMENTATION
DRUG EXPOSURE
ERYTHROPOIESIS
FEMALE
GENOTOXICITY
HEMATOCRIT
LIVER INJURY
LONG TERM EXPOSURE
MEMBRANE STABILIZATION
NEPHROTOXICITY
NICKEL HYPERSENSITIVITY
NONHUMAN
OXIDATIVE STRESS
PILOT STUDY
POLYMERASE CHAIN REACTION
RANDOM AMPLIFIED POLYMORPHIC DNA
RAT
SPECTROPHOTOMETRY
TRANSMISSION ELECTRON MICROSCOPY
URI: http://hdl.handle.net/10995/75282
metadata.dc.rights: info:eu-repo/semantics/openAccess
SCOPUS ID: 85064830224
WOS ID: 000465258100083
PURE ID: 9312001
ISSN: 1661-6596
DOI: 10.3390/ijms20071778
metadata.dc.description.sponsorship: For modeling chronic intoxication development under low-level but long-term inhalation exposures to NiO nanoparticles, the experiments were carried out on outbred white female rats from our own breeding colony with an initial body weight of 150–220 g, with a minimum of 12 animals in exposed and control groups. Rats were housed in conventional conditions, breathed unfiltered air, and were fed standard balanced food. The experiments were planned and implemented in accordance with the “International guiding principles for biomedical research involving animals” developed by the Council for International Organizations of Medical Sciences (1985) and were approved by the Ethics Committee of the Ekaterinburg Medical Research Center Medical for Prophylaxis and Health Protection in Industrial Workers.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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