Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/51424
Title: Modeling of heterogeneity in electrical and mechanical properties of guinea pig ventricular myocytes
Authors: Vasilyeva, Anastasia
Solovyova, Olga
Issue Date: 2012
Publisher: IEEE Computer Society
Abstract: Heterogeneity of myocardium proved to be important for understanding heart physiology and pathophysiology. In contrast to a number of papers addressing the electrophysiological heterogeneity of cardiomyocytes, much less is known about heterogeneity of their mechanical function. The aim of this study was to develop mathematical models of the electrical and mechanical function of cardiomyocytes from sub-epi- and sub-endocardial ventricular layers that take into account specific features of intracellular mechanisms underlying pronounced regional differences in the functional properties of the cells in guinea pig. Using the developed models we quantitatively tested several hypotheses on possible contribution of the transmural gradient in Na+/Ca2+ exchange currents to the cellular function. The simulations consist with a hypothesis that transmural gradient in Na+/Ca2+ exchange currents may partially result from the heterogeneity in Na+/K + pump in cells from different transmural regions. © 2012 CCAL.
Keywords: BIOMECHANICS
CALCIUM
CARDIOLOGY
ELECTRIC PROPERTIES
ELECTROPHYSIOLOGY
MATHEMATICAL MODELS
MECHANICAL PROPERTIES
SODIUM
CELLULAR FUNCTION
ELECTRICAL AND MECHANICAL PROPERTIES
EXCHANGE CURRENTS
FUNCTIONAL PROPERTIES
MECHANICAL FUNCTIONS
PATHOPHYSIOLOGY
REGIONAL DIFFERENCES
VENTRICULAR MYOCYTES
ION EXCHANGE
URI: https://elar.urfu.ru/handle/10995/51424
http://hdl.handle.net/10995/51424
Conference name: 39th Computing in Cardiology Conference, CinC 2012
Conference date: 09.09.2012-12.09.2012
SCOPUS ID: 84875638637
WOS ID: 000320270700114
PURE ID: 1098931
ISSN: 2325-8861
ISBN: 9781467320740
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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