Please use this identifier to cite or link to this item:
|Title:||Consecutive S N H and Suzuki-Miyaura cross-coupling reactions-an efficient synthetic strategy to pyrimidines bearing pyrrole and indole fragments|
|Authors:||Verbitskiy, Egor V.|
Rusinov, Gennady L.
Charushin, Valery N.
Chupakhin, Oleg N.
Cheprakova, Ekaterina M.
Slepukhin, Pavel A.
Pervova, Marina G.
Ezhikova, Marina A.
Kodess, Mikhail I.
|Citation:||Consecutive S N H and Suzuki-Miyaura cross-coupling reactions-an efficient synthetic strategy to pyrimidines bearing pyrrole and indole fragments / Egor V. Verbitskiy, Gennady L. Rusinov, Valery N. Charushin, Oleg N. Chupakhin, Ekaterina M. Cheprakova, Pavel A. Slepukhin, Marina G. Pervova, Marina A. Ezhikova, Mikhail I. Kodess // European Journal of Organic Chemistry. — 2012. — № 33. — P. 6612-6621.|
|Abstract:||The combination of the Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen reactions is a versatile tool for the syntheses of 4-(1R-pyrrol-2-yl)-and 4-(1R-indol-3-yl)-5-(hetero)aryl-substituted pyrimidines from commercially available 5-bromopyrimidine. The S N H [AE, (addition-elimination)] and S N H [AO, (addition-oxidation)] reactions of 5-bromopyrimidine with pyrroles and indoles were studied by gas chromatography-mass spectrometry. The structures of the intermediate σ H adducts as well as the pyrrole-(hetero)arylpyrimidine and indole-(hetero)arylpyrimidine dyads were established for the first time by X-ray crystal structure analysis. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.