1,3-Dipolar cycloadditions of nonstabilised azomethine ylides at 3-substituted coumarins: Synthesis of 1-benzopyrano[3,4-c]pyrrolidines

Abstract

Reaction of 3-substituted coumarins with N-alkyl-α-amino acids and aldehydes proceeds regio- and stereoselectively to give 1-benzopyrano[3,4-c] pyrrolidines as a result of 1,3-dipolar cycloaddition of the intermediate azomethine ylides at the Δ 3-bond of the coumarins. © 2012 Mendeleev Communications. All rights reserved.