Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/42663
Title: Хромато-масс-спектрометрическое определение тиодиуксусной кислоты в моче
Other Titles: Chromatography-mass-spectrometry determination of thiodiacetic acid in urine
Authors: Журба, О. М.
Алексеенко, А. Н.
Шаяхметов, С. Ф.
Zhurba, O. M.
Alekseenko, A. N.
Shaiakhmetov, S. F.
Issue Date: 2013
Publisher: Уральский федеральный университет
Citation: Журба О. М. Хромато-масс-спектрометрическое определение тиодиуксусной кислоты в моче / О. М. Журба, А. Н. Алексеенко, С. Ф. Шаяхметов // Аналитика и контроль. — 2013. — № 4. — С. 445-451.
Abstract: Оптимизирована пробоподготовка мочи для ГХ-МС определения тиодиуксусной кислоты в диапазоне от 0.1 до 10 мкг/см
We used the gas chromatograph Agilent 7890A with a flame ionization detector and gas chromatography-mass spectrometer Agilent 5975C in the present work. Dimethyl ester of thiodiacetic acid was identified by the absolute retention time (10.36 min), and the ratio of the peak intensities of the ions 146 (primary) and 178 (confirmation). The calibration curve is characterized by a linear dependence of the chromatographic peak area for the ion at m / z 146 of the mass concentration of the analyte in the range of 0.1 – 10 μg/sm3. Optimal chromatographic separation of the mixture components and a sufficiently high detection sensitivity can be achieved with a temperature gradient and splitless. To combine the derivatization and extraction in a single container with a minimum flow rate of organic solvents used chromatographic vial capacity of 1.5 cm
Keywords: THIODIACETIC ACID IN URINE
LIQUID-LIQUID MICROEXTRACTION
DERIVATIZATION BY METHANOL
GAS CHROMATOGRAPHY-MASS-SPECTROMETRY OF BIOLOGICAL MATRIXES
URI: http://hdl.handle.net/10995/42663
ISSN: 2073-1442
DOI: 10.15826/analitika.2013.17.4.010
Origin: Аналитика и контроль. 2013. № 4
Appears in Collections:Аналитика и контроль

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