Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/31793
Title: Synthesis of 5-thiocarbomoyl- and 5-(thiazol-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbonitriles
Authors: Poluikova, A. A.
Platonova, A. Yu.
Glukhareva, T. V.
Morzherin, Yu. Yu.
Issue Date: 2015
Citation: Synthesis of 5-thiocarbomoyl- and 5-(thiazol-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbonitriles / А. А. Poluikova, А. Yu. Platonova, Т. V. Glukhareva, Yu. Yu. Morzherin // Chimica Techno Acta. — 2015. — Vol. 2. № 2. — С. 98-102.
Abstract: The tert-amino effect cyclizations are an efficient and convenient route to synthetically as well as biologically important ring-fused tetrahydroquinolines. The method is operationally simple and highly diastereoselective. Herein we represent our studies of the tert-amino effect reaction ortho-dialkylaminobenzaldehydes and cyanthioacetamide or [4-aryl-1,3-thiazole-2yl]acetonitrile. It was found 9-chloro-5-(4-phenylthiazole-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbinitrile can easily be obtained from 9-chloro-5-cyano-2,3,4,4а,5,6-hexahydro-1H-pyrido[1,2-a] quinoline-5-carbothioamide and α-bromoacetophenone by condensation.
Keywords: TERT-AMINO EFFECT
QUINOLINE
CYCLIZATION
THIOAMIDE
ТРЕТ-АМИНО ЭФФЕКТ
АЗОТСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ
ЦИКЛИЗАЦИЯ
ТИОАМИДЫ
URI: http://hdl.handle.net/10995/31793
RSCI ID: https://elibrary.ru/item.asp?id=23785864
ISSN: 2409-5613
Other versions: http://hdl.handle.net/10995/31794
DOI: http://dx.doi.org/10.15826/chimtech.2015.2.2.010
Origin: Chimica Techno Acta. 2015. Vol. 2. № 2.
Appears in Collections:Chimica Techno Acta

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