Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/27253
Title: Mössbauer spectroscopy of the iron cores in human liver ferritin, ferritin in normal human spleen and ferritin in spleen from patient with primary myelofibrosis: Preliminary results of comparative analysis
Authors: Oshtrakh, M. I.
Alenkina, I. V.
Vinogradov, A. V.
Konstantinova, T. S.
Kuzmann, E.
Semionkin, V. A.
Issue Date: 2013
Citation: Mössbauer spectroscopy of the iron cores in human liver ferritin, ferritin in normal human spleen and ferritin in spleen from patient with primary myelofibrosis: Preliminary results of comparative analysis / M. I. Oshtrakh, I. V. Alenkina, A. V. Vinogradov [et al.] // BioMetals. — 2013. — Vol. 26. — № 2. — P. 229-239.
Abstract: Comparative study of human liver ferritin and spleen tissues from healthy human and patient with primary myelofibrosis was carried out using Mössbauer spectroscopy with a high velocity resolution at 295 and 90 K and with a low velocity resolution at 20 K. The results obtained demonstrated that the iron content in patient's spleen in the form of iron storage proteins was about ten times larger than that in normal tissue. However, in the case of patient with primary myelofibrosis the magnetic anisotropy energy barrier differed from that in normal case and, probably, the iron core size was supposed to be slightly larger than that in both normal spleen tissue and normal human liver ferritin in contrast to well-known data for iron overload in patients with thalassemia accompanied by the iron-core size increase. Therefore, the iron overload in the case of patient with primary myelofibrosis may be related to increase in the ferritin content mainly. It was also found that Mössbauer hyperfine parameters for normal and patient's spleen and normal human liver ferritin demonstrated some small differences related, probably, to some small structural variations in the ferritin iron cores of patient's spleen. © 2013 Springer Science+Business Media New York.
Keywords: IRON STORAGE PROTEINS
MÖSSBAUER SPECTROSCOPY
PRIMARY MYELOFIBROSIS
SPLEEN TISSUES
FERRITIN
IRON
ANISOTROPY
ARTICLE
BETA THALASSEMIA
COMPARATIVE STUDY
CONTROLLED STUDY
HUMAN
HUMAN CELL
HUMAN TISSUE
IRON OVERLOAD
IRON STORAGE
LIVER LEVEL
MOSSBAUER SPECTROSCOPY
MYELOID METAPLASIA
ROOM TEMPERATURE
SIGNAL NOISE RATIO
TRANSMISSION ELECTRON MICROSCOPY
FERRITINS
HUMANS
IRON
LIVER
PRIMARY MYELOFIBROSIS
SPECTROSCOPY, MOSSBAUER
SPLEEN
URI: http://hdl.handle.net/10995/27253
SCOPUS ID: 84877876769
WOS ID: 000319802100003
PURE ID: 915746
ISSN: 0966-0844
DOI: 10.1007/s10534-012-9602-2
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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