Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/26799
Title: Comparative in vivo assessment of some adverse bioeffects of equidimensional gold and silver nanoparticles and the attenuation of nanosilver's effects with a complex of innocuous bioprotectors
Authors: Katsnelson, B. A.
Privalova, L. I.
Gurvich, V. B.
Makeyev, O. H.
Shur, V. Y.
Beikin, Y. B.
Sutunkova, M. P.
Kireyeva, E. P.
Minigalieva, I. A.
Loginova, N. V.
Vasilyeva, M. S.
Korotkov, A. V.
Shuman, E. A.
Vlasova, L. A.
Shishkina, E. V.
Tyurnina, A. E.
Kozin, R. V.
Valamina, I. E.
Pichugova, S. V.
Tulakina, L. G.
Issue Date: 2013
Citation: Comparative in vivo assessment of some adverse bioeffects of equidimensional gold and silver nanoparticles and the attenuation of nanosilver's effects with a complex of innocuous bioprotectors / B. A. Katsnelson, L. I. Privalova, V. B. Gurvich [et al.] // International Journal of Molecular Sciences. — 2013. — Vol. 14. — № 2. — P. 2449-2483.
Abstract: Stable suspensions of nanogold (NG) and nanosilver (NS) with mean particle diameter 50 and 49 nm, respectively, were prepared by laser ablation of metals in water. To assess rat's pulmonary phagocytosis response to a single intratracheal instillation of these suspensions, we used optical, transmission electron, and semi-contact atomic force microscopy. NG and NS were also repeatedly injected intraperitoneally into rats at a dose of 10 mg/kg (0.5 mg per mL of deionized water) three times a week, up to 20 injections. A group of rats was thus injected with NS after oral administration of a "bioprotective complex" (BPC) comprised of pectin, multivitamins, some amino acids, calcium, selenium, and omega-3 PUFA. After the termination of the injections, many functional and biochemical indices and histopathological features of the spleen, kidneys and liver were evaluated for signs of toxicity, and accumulation of NG or NS in these organs was measured. From the same rats, we obtained cell suspensions of different tissues for performing the RAPD test. It was demonstrated that, although both nanometals were adversely bioactive in all respects considered in this study, NS was more noxious as compared with NG, and that the BPC tested by us attenuated both the toxicity and genotoxicity of NS. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Keywords: BIOPROTECTORS
BRONCHOALVEOLAR LAVAGE
GENOTOXICITY
NANOGOLD
NANOSILVER
SUBCHRONIC TOXICITY
ACETYLCYSTEINE
AMINO ACID
CALCIUM
FISH OIL
GLUTAMATE SODIUM
GLYCINE
GOLD NANOPARTICLE
MULTIVITAMIN
PECTIN
PROTECTIVE AGENT
SELENIUM
SILVER NANOPARTICLE
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL TISSUE
ARTICLE
ATOMIC FORCE MICROSCOPY
CELL NUCLEUS
CELL SUSPENSION
CELLULAR DISTRIBUTION
CONTROLLED STUDY
DNA FRAGMENTATION
DRUG CYTOTOXICITY
ENDOCYTOSIS
FEMALE
GENOTOXICITY
HISTOPATHOLOGY
INTERNALIZATION
KIDNEY
LIVER
LUNG ALVEOLUS MACROPHAGE
MITOCHONDRION
NANOTOXICOLOGY
NEUTROPHIL
NONHUMAN
PHAGOCYTOSIS
RAT
SPLEEN
TOXICOKINETICS
TRANSMISSION ELECTRON MICROSCOPY
URI: http://hdl.handle.net/10995/26799
SCOPUS ID: 84875109377
WOS ID: 000315397900012
PURE ID: 902887
ISSN: 1661-6596
DOI: 10.3390/ijms14022449
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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