1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/141748
Полная запись метаданных
Поле DCЗначениеЯзык
dc.contributor.authorObiedallah, M. M.en
dc.contributor.authorMironov, M. A.en
dc.contributor.authorBelyaev, D. V.en
dc.contributor.authorEne, A.en
dc.contributor.authorVakhrusheva, D. V.en
dc.contributor.authorKrasnoborova, S. Y.en
dc.contributor.authorBershitsky, S. Y.en
dc.contributor.authorShchepkin, D. V.en
dc.contributor.authorMinin, A. S.en
dc.contributor.authorIshmetova, R. I.en
dc.contributor.authorIgnatenko, N. K.en
dc.contributor.authorTolshchina, S. G.en
dc.contributor.authorFedorova, O. V.en
dc.contributor.authorRusinov, G. L.en
dc.date.accessioned2025-02-25T11:02:26Z-
dc.date.available2025-02-25T11:02:26Z-
dc.date.issued2024-
dc.identifier.citationObiedallah, M., Mironov, M., Belyaev, D., Ene, A., Vakhrusheva, D., Krasnoborova, S. Y., Bershitsky, S., Shchepkin, D., Minin, A., Ishmetova, R., Ignatenko, N., Tolshchina, S., Fedorova, O., & Rusinov, G. L. (2024). Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles. Scientific Reports, 14(1), [524]. https://doi.org/10.1038/s41598-023-49576-2apa_pure
dc.identifier.issn2045-2322-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access; Gold Open Access3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85181455194&doi=10.1038%2fs41598-023-49576-2&partnerID=40&md5=8219af24d0b0219307c3e99e4aa7bf141
dc.identifier.otherhttps://www.nature.com/articles/s41598-023-49576-2.pdfpdf
dc.identifier.urihttp://elar.urfu.ru/handle/10995/141748-
dc.description.abstractThe treatment of tuberculosis is still a challenging process due to the widespread of pathogen strains resistant to antibacterial drugs, as well as the undesirable effects of anti-tuberculosis therapy. Hence, the development of safe and effective new anti-antitubercular agents, in addition to suitable nanocarrier systems, has become of utmost importance and necessity. Our research aims to develop liposomal vesicles that contain newly synthesized compounds with antimycobacterial action. The compound being studied is a derivative of imidazo-tetrazine named 3-(3,5-dimethylpyrazole-1-yl)-6-(isopropylthio) imidazo [1,2-b] [1,2,4,5] tetrazine compound. Several factors that affect liposomal characteristics were studied. The maximum encapsulation efficiency was 53.62 ± 0.09. The selected liposomal formulation T8* possessed a mean particle size of about 205.3 ± 3.94 nm with PDI 0.282, and zeta potential was + 36.37 ± 0.49 mv. The results of the in vitro release study indicated that the solubility of compound I was increased by its incorporation in liposomes. The free compound and liposomal preparation showed antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) at MIC value 0.94–1.88 μg/ml. We predict that the liposomes may be a good candidate for delivering new antitubercular drugs. © 2024, The Author(s).en
dc.description.sponsorshipMinistry of Higher Education and Scientific Research, MHESR; Universitatea 'Dunărea de Jos' Galați, UDJG; Ministry of Education and Science of the Russian Federation, Minobrnauka, (075-15-2020-777); Ministry of Education and Science of the Russian Federation, Minobrnaukaen
dc.description.sponsorshipThis research was funded by the Ministry of Science and Higher Education of the Russian Federation (Agreement on the provision of grants from the federal budget in the form of subsidies under paragraph 4 of Article 78.1 of the Budget Code of the Russian Federation, Moscow, 1 October 2020 No. 075-15-2020-777). Manar M. Obiedallah would like to acknowledge the partial financial support provided by the Egyptian Ministry of Higher Education and Scientific Research. The work of author AE was supported by Dunarea de Jos University of Galati, Romania.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherNature Researchen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightscc-byother
dc.sourceScientific Reports2
dc.sourceScientific Reportsen
dc.subjectANTITUBERCULAR AGENTSen
dc.subjectHUMANSen
dc.subjectLIPOSOMESen
dc.subjectMICROBIAL SENSITIVITY TESTSen
dc.subjectMYCOBACTERIUM TUBERCULOSISen
dc.subjectTUBERCULOSISen
dc.subjectLIPOSOMEen
dc.subjectTUBERCULOSTATIC AGENTen
dc.subjectHUMANen
dc.subjectMICROBIAL SENSITIVITY TESTen
dc.subjectMICROBIOLOGYen
dc.subjectMYCOBACTERIUM TUBERCULOSISen
dc.subjectTUBERCULOSISen
dc.titleOptimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesiclesen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1038/s41598-023-49576-2-
dc.identifier.scopus85181455194-
local.contributor.employeeObiedallah M.M., Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypten
local.contributor.employeeMironov M.A., Institute of Chemical Technology, Ural Federal University, Yekaterinburg, Russian Federationen
local.contributor.employeeBelyaev D.V., I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federation, National Medical Research Center of Phthisiopulmonology and Infectious Diseases, 22 Parts’ezda St., 50, Yekaterinburg, 620039, Russian Federationen
local.contributor.employeeEne A., INPOLDE Research Center, Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, Dunarea de Jos University of Galati, 47 Domneasca Street, Galati, 800008, Romaniaen
local.contributor.employeeVakhrusheva D.V., National Medical Research Center of Phthisiopulmonology and Infectious Diseases, 22 Parts’ezda St., 50, Yekaterinburg, 620039, Russian Federationen
local.contributor.employeeKrasnoborova S.Y., National Medical Research Center of Phthisiopulmonology and Infectious Diseases, 22 Parts’ezda St., 50, Yekaterinburg, 620039, Russian Federationen
local.contributor.employeeBershitsky S.Y., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, 620049, Russian Federationen
local.contributor.employeeShchepkin D.V., Institute of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federationen
local.contributor.employeeMinin A.S., M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, S.Kovalevskaya St. 18, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeIshmetova R.I., I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeIgnatenko N.K., I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeTolshchina S.G., I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeFedorova O.V., I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeRusinov G.L., Institute of Chemical Technology, Ural Federal University, Yekaterinburg, Russian Federation, I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.issue1-
local.volume14-
dc.identifier.wos001136960700001-
local.contributor.departmentDepartment of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypten
local.contributor.departmentInstitute of Chemical Technology, Ural Federal University, Yekaterinburg, Russian Federationen
local.contributor.departmentI. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str. 22, Yekaterinburg, 620108, Russian Federationen
local.contributor.departmentNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, 22 Parts’ezda St., 50, Yekaterinburg, 620039, Russian Federationen
local.contributor.departmentINPOLDE Research Center, Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, Dunarea de Jos University of Galati, 47 Domneasca Street, Galati, 800008, Romaniaen
local.contributor.departmentInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, 620049, Russian Federationen
local.contributor.departmentInstitute of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federationen
local.contributor.departmentM.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, S.Kovalevskaya St. 18, Yekaterinburg, 620108, Russian Federationen
local.identifier.pure51655727-
local.description.order524
local.identifier.eid2-s2.0-85181455194-
local.fund.rsfNational Science Foundation, NSF, (2053429, 2126792); National Science Foundation, NSF
local.fund.rsfValeriy Y. Ivanov acknowledges the support of the U.S. National Science Foundation (NSF) CMMI program award # 2053429, and the NSF Navigating the New Arctic Program Track-I grant 2126792.
local.identifier.wosWOS:001136960700001-
local.identifier.pmid38177202-
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Файлы этого ресурса:
Файл Описание РазмерФормат 
2-s2.0-85181455194.pdf1,35 MBAdobe PDFПросмотреть/Открыть
Показать базовое описание ресурса Статистика


Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.