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http://elar.urfu.ru/handle/10995/141476
Название: | On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles |
Авторы: | Minigaliyeva, I. A. Klinova, S. V. Sutunkova, M. P. Ryabova, Y. V. Valamina, I. E. Shelomentsev, I. G. Shtin, T. N. Bushueva, T. V. Protsenko, Y. L. Balakin, A. A. Lisin, R. V. Kuznetsov, D. A. Katsnelson, B. A. Toropova, L. V. |
Дата публикации: | 2024 |
Издатель: | Springer |
Библиографическое описание: | Minigaliyeva, I. A., Klinova, S., Sutunkova, M. P., Ryabova, Y. V., Valamina, I. E., Shelomentsev, I. G., Shtin, T. N., Bushueva, T., Protsenko, Y. L., Balakin, A. A., Lisin, R. V., Kuznetsov, D., Katsnelson, B., & Toropova, L. (2024). On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles. Cardiovascular Toxicology, 24(1 (SI)), 49-61. https://doi.org/10.1007/s12012-023-09814-5 |
Аннотация: | Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 ± 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia. Graphical Abstract: (Figure presented.) © The Author(s) 2023. |
Ключевые слова: | CARDIOTOXICITY EXPERIMENTAL STUDY NANOPARTICLES RATS ANIMALS LEAD MALE NANOPARTICLES OXIDATIVE STRESS OXIDES RATS LEAD OXIDE NANOPARTICLE LEAD LEAD OXIDE NANOPARTICLE OXIDE ANEMIA ANIMAL CELL ANIMAL EXPERIMENT ANIMAL MODEL ANIMAL TISSUE ARTICLE BIOCHEMISTRY BLOOD PRESSURE MEASUREMENT CARDIAC MUSCLE CELL CARDIOTOXICITY CONTROLLED STUDY DISEASE COURSE ELECTROCARDIOGRAM HEART MUSCLE CONTRACTILITY HEMATOLOGICAL PARAMETERS HISTOLOGY HYPOCALCEMIA HYPOXIA MALE NON INVASIVE PROCEDURE NONHUMAN OXIDATIVE STRESS RAT ULTRASTRUCTURE URINE LEVEL ANIMAL CHEMISTRY |
URI: | http://elar.urfu.ru/handle/10995/141476 |
Условия доступа: | info:eu-repo/semantics/openAccess cc-by |
Идентификатор SCOPUS: | 85180207971 |
Идентификатор WOS: | 001126380300003 |
Идентификатор PURE: | 52351840 |
ISSN: | 1530-7905 1559-0259 |
DOI: | 10.1007/s12012-023-09814-5 |
Сведения о поддержке: | Ministry of Education and Science of the Russian Federation, Minobrnauka; Ural Federal University, UrFU Open Access funding enabled and organized by Projekt DEAL. The analysis was supported by the Ministry of Science and Higher Education of the Russian Federation within the “Priority – 2030” Development Program of the Ural Federal University; the experimental data were provided by Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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Файл | Описание | Размер | Формат | |
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2-s2.0-85180207971.pdf | 5,1 MB | Adobe PDF | Просмотреть/Открыть |
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