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Название: On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles
Авторы: Minigaliyeva, I. A.
Klinova, S. V.
Sutunkova, M. P.
Ryabova, Y. V.
Valamina, I. E.
Shelomentsev, I. G.
Shtin, T. N.
Bushueva, T. V.
Protsenko, Y. L.
Balakin, A. A.
Lisin, R. V.
Kuznetsov, D. A.
Katsnelson, B. A.
Toropova, L. V.
Дата публикации: 2024
Издатель: Springer
Библиографическое описание: Minigaliyeva, I. A., Klinova, S., Sutunkova, M. P., Ryabova, Y. V., Valamina, I. E., Shelomentsev, I. G., Shtin, T. N., Bushueva, T., Protsenko, Y. L., Balakin, A. A., Lisin, R. V., Kuznetsov, D., Katsnelson, B., & Toropova, L. (2024). On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles. Cardiovascular Toxicology, 24(1 (SI)), 49-61. https://doi.org/10.1007/s12012-023-09814-5
Аннотация: Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 ± 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia. Graphical Abstract: (Figure presented.) © The Author(s) 2023.
Ключевые слова: CARDIOTOXICITY
EXPERIMENTAL STUDY
NANOPARTICLES
RATS
ANIMALS
LEAD
MALE
NANOPARTICLES
OXIDATIVE STRESS
OXIDES
RATS
LEAD OXIDE
NANOPARTICLE
LEAD
LEAD OXIDE
NANOPARTICLE
OXIDE
ANEMIA
ANIMAL CELL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMAL TISSUE
ARTICLE
BIOCHEMISTRY
BLOOD PRESSURE MEASUREMENT
CARDIAC MUSCLE CELL
CARDIOTOXICITY
CONTROLLED STUDY
DISEASE COURSE
ELECTROCARDIOGRAM
HEART MUSCLE CONTRACTILITY
HEMATOLOGICAL PARAMETERS
HISTOLOGY
HYPOCALCEMIA
HYPOXIA
MALE
NON INVASIVE PROCEDURE
NONHUMAN
OXIDATIVE STRESS
RAT
ULTRASTRUCTURE
URINE LEVEL
ANIMAL
CHEMISTRY
URI: http://elar.urfu.ru/handle/10995/141476
Условия доступа: info:eu-repo/semantics/openAccess
cc-by
Идентификатор SCOPUS: 85180207971
Идентификатор WOS: 001126380300003
Идентификатор PURE: 52351840
ISSN: 1530-7905
1559-0259
DOI: 10.1007/s12012-023-09814-5
Сведения о поддержке: Ministry of Education and Science of the Russian Federation, Minobrnauka; Ural Federal University, UrFU
Open Access funding enabled and organized by Projekt DEAL. The analysis was supported by the Ministry of Science and Higher Education of the Russian Federation within the “Priority – 2030” Development Program of the Ural Federal University; the experimental data were provided by Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers.
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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