More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy

Abstract

Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but there is a large body of literature that indicates the relationship between spindle activity and neural plasticity. Many of the spindle parameters (frequency, configuration, duration, density, and topography) vary significantly throughout life. However, the long duration, asynchrony and sharp morphology are the most distinctive characteristics of sleep spindles in infants. This unique infantile phenotype of sleep spindles typically changes after approximately one year of postnatal life in humans. Considering that EEG reflects brain electrochemical activity, there is evidence to suggest that substantial neurochemical events underlie these changes. In this paper, we hypothesize that the GABA (gammaaminobutyric acid) shift is a key event influencing the sleep spindle phenotype during infancy. We briefly review evidence for the relation between infantile sleep spindles and depolarizing GABA transmission occurring in the developing brain. © 2022 Brazilian Association of Sleep and Latin American Federation of Sleep Societies. All rights reserved.