1. Электронный научный архив УрФУ
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  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
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dc.contributor.authorSutunkova, M. P.en
dc.contributor.authorMinigalieva, I. A.en
dc.contributor.authorShelomencev, I. G.en
dc.contributor.authorPrivalova, L. I.en
dc.contributor.authorRyabova, Y. V.en
dc.contributor.authorTazhigulova, A. V.en
dc.contributor.authorAmromin, L. A.en
dc.contributor.authorMinigalieva, R. F.en
dc.contributor.authorSutunkova, Y. M.en
dc.contributor.authorGurvich, V. B.en
dc.contributor.authorMakoveeva, E. V.en
dc.contributor.authorToropova, L. V.en
dc.date.accessioned2024-04-08T11:07:29Z-
dc.date.available2024-04-08T11:07:29Z-
dc.date.issued2022-
dc.identifier.citationSutunkova, MP, Minigalieva, IA, Shelomencev, IG, Privalova, LI, Ryabova, YV, Tazhigulova, AV, Amromin, LA, Minigalieva, RF, Sutunkova, YM, Gurvich, VB, Makoveeva, EV & Toropova, LV 2022, 'Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats', Scientific Reports, Том. 12, № 1, 19444. https://doi.org/10.1038/s41598-022-24018-7harvard_pure
dc.identifier.citationSutunkova, M. P., Minigalieva, I. A., Shelomencev, I. G., Privalova, L. I., Ryabova, Y. V., Tazhigulova, A. V., Amromin, L. A., Minigalieva, R. F., Sutunkova, Y. M., Gurvich, V. B., Makoveeva, E. V., & Toropova, L. V. (2022). Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats. Scientific Reports, 12(1), [19444]. https://doi.org/10.1038/s41598-022-24018-7apa_pure
dc.identifier.issn2045-2322-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access; Gold Open Access; Green Open Access3
dc.identifier.otherhttps://www.nature.com/articles/s41598-022-24018-7.pdf1
dc.identifier.otherhttps://www.nature.com/articles/s41598-022-24018-7.pdfpdf
dc.identifier.urihttp://elar.urfu.ru/handle/10995/131470-
dc.description.abstractWhite outbred female rats were exposed intranasally to 50-µL of suspension of lead oxide nanoparticles (PbO NPs) at a concentration of 0.5 mg/mL thrice a week during six weeks. A control group of rats was administered deionized water in similar volumes and conditions. The developed intoxication was manifested by altered biochemical and cytochemical parameters, as well as behavioral reactions of animals. Using electron microscopy and energy-dispersive X-ray spectroscopy techniques, we revealed deposition of PbO NPs in the olfactory bulb, but not in basal ganglia, and an increase in the number of axons with damage to the myelin sheath in the tissues of olfactory bulb and basal ganglia, changes in the ultrastructure of mitochondria of neurons in the tissues of olfactory bulb and basal ganglia of the brain, and differences in the mitochondrial profile of neurons in different regions of the rat brain. Our results collectively suggest that the central nervous system may be a target of low-level toxicity of lead oxide nanoparticles. © 2022, The Author(s).en
dc.description.sponsorshipUral Federal University Program of Developmenten
dc.description.sponsorshipYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workersen
dc.description.sponsorshipMinistry of Education and Science of the Russian Federation, Minobrnaukaen
dc.description.sponsorshipThe research funding from Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers for funding the experimental materials and facilities is gratefully acknowledged. The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority–2030 Program) for experiment implementation and analysis of its results is gratefully acknowledged.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherNature Researchen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightscc-byother
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/unpaywall
dc.sourceScientific Reports2
dc.sourceScientific Reportsen
dc.subjectADMINISTRATION, INTRANASALen
dc.subjectANIMALSen
dc.subjectBRAINen
dc.subjectFEMALEen
dc.subjectMICROSCOPY, ELECTRONen
dc.subjectNANOPARTICLESen
dc.subjectOLFACTORY BULBen
dc.subjectRATSen
dc.subjectLEAD OXIDEen
dc.subjectNANOPARTICLEen
dc.subjectANIMALen
dc.subjectBRAINen
dc.subjectCHEMISTRYen
dc.subjectELECTRON MICROSCOPYen
dc.subjectFEMALEen
dc.subjectINTRANASAL DRUG ADMINISTRATIONen
dc.subjectOLFACTORY BULBen
dc.subjectRATen
dc.titleElectron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in ratsen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1038/s41598-022-24018-7-
dc.identifier.scopus85141972679-
local.contributor.employeeSutunkova M.P., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.employeeMinigalieva I.A., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federation, Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeShelomencev I.G., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.employeePrivalova L.I., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federation, Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeRyabova Y.V., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federation, Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeTazhigulova A.V., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.employeeAmromin L.A., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.employeeMinigalieva R.F., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federation, Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeSutunkova Y.M., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federation, Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeGurvich V.B., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.employeeMakoveeva E.V., Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.employeeToropova L.V., Laboratory of Mathematical Modeling of Physical and Chemical Processes in Multiphase Media, Department of Theoretical and Mathematical Physics, Ural Federal University, Lenin Ave., 51, Ekaterinburg, 620000, Russian Federation, Otto-Schott-Institut Für Materialforschung, Friedrich-Schiller-Universität-Jena, Jena, 07743, Germanyen
local.issue1-
local.volume12-
dc.identifier.wos000883823800070-
local.contributor.departmentYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, Yekaterinburg, 620014, Russian Federationen
local.contributor.departmentLaboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi‑Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, Yekaterinburg, 620000, Russian Federationen
local.contributor.departmentLaboratory of Mathematical Modeling of Physical and Chemical Processes in Multiphase Media, Department of Theoretical and Mathematical Physics, Ural Federal University, Lenin Ave., 51, Ekaterinburg, 620000, Russian Federationen
local.contributor.departmentOtto-Schott-Institut Für Materialforschung, Friedrich-Schiller-Universität-Jena, Jena, 07743, Germanyen
local.identifier.pure31781025-
local.identifier.pure5791635a-3134-40b1-8860-a0c24c92a318uuid
local.description.order19444-
local.identifier.eid2-s2.0-85141972679-
local.identifier.wosWOS:000883823800070-
local.identifier.pmid36376368-
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