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Название: Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action
Авторы: Grzhegorzhevskii, K.
Tonkushina, M.
Gushchin, P.
Gagarin, I.
Ermoshin, A.
Belova, K.
Prokofyeva, A.
Ostroushko, A.
Novikov, A.
Дата публикации: 2023
Издатель: MDPI
Библиографическое описание: Grzhegorzhevskii, K, Tonkushina, M, Gushchin, P, Gagarin, I, Ermoshin, A, Belova, K, Prokofyeva, A, Ostroushko, A & Novikov, A 2023, 'Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action', Inorganics, Том. 11, № 1, 9. https://doi.org/10.3390/inorganics11010009
Grzhegorzhevskii, K., Tonkushina, M., Gushchin, P., Gagarin, I., Ermoshin, A., Belova, K., Prokofyeva, A., Ostroushko, A., & Novikov, A. (2023). Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action. Inorganics, 11(1), [9]. https://doi.org/10.3390/inorganics11010009
Аннотация: The association process between the tetracycline (TC) antibiotic molecule and Keplerate-type nanocluster polyoxometalate (POM) {Mo72Fe30} was studied in aqueous solution. The novel supramolecular ensemble {Mo72Fe30}@TC12.5 was produced, its composition and structure were revealed by means of elemental analysis (C, N, H) and vibrational spectroscopy (IR and Raman). Based on the spectral data, the POM structure’s integrity was confirmed and binding sites of TC with the Keplerate {Mo72Fe30} surface were found. Due to thermogravimetric analysis (TG) and in-situ Raman spectroscopy during the process of {Mo72Fe30}@TC12.5 thermal destruction, we showed a significant change in the phase composition of POM’s destruction products after association with TC. The antibacterial activity of the obtained complex {Mo72Fe30}@TC12.5 was examined. The experimental results allowed us to note the partial inhibition of TC’s antibacterial activity owing to the coordination of TC to FeIII centers, in turn, which hinders the participation of TC in coordination via Mg2+ of ribosomal subunits 30S in bacteria. © 2022 by the authors.
Ключевые слова: ANTIBIOTIC ACTION
KEPLERATE
POLYOXOMETALATE
TETRACYCLINE
VIBRATIONAL SPECTROSCOPY
URI: http://elar.urfu.ru/handle/10995/130870
Условия доступа: info:eu-repo/semantics/openAccess
cc-by
Текст лицензии: https://creativecommons.org/licenses/by/4.0/
Идентификатор SCOPUS: 85146663805
Идентификатор WOS: 000914889100001
Идентификатор PURE: 33632375
ISSN: 2304-6740
DOI: 10.3390/inorganics11010009
Сведения о поддержке: Ministry of Education and Science of the Russian Federation, Minobrnauka
The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged.
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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