1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/130834
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEdilova, Y. O.en
dc.contributor.authorOsipova, E. A.en
dc.contributor.authorSlepukhin, P. A.en
dc.contributor.authorSaloutin, V. I.en
dc.contributor.authorBazhin, D. N.en
dc.date.accessioned2024-04-05T16:34:02Z-
dc.date.available2024-04-05T16:34:02Z-
dc.date.issued2023-
dc.identifier.citationEdilova, YO, Osipova, EA, Slepukhin, P, Saloutin, V & Bazhin, D 2023, 'Exploring Three Avenues: Chemo- and Regioselective Transformations of 1,2,4-Triketone Analogs into Pyrazoles and Pyridazinones', International Journal of Molecular Sciences, Том. 24, № 18, 14234. https://doi.org/10.3390/ijms241814234harvard_pure
dc.identifier.citationEdilova, Y. O., Osipova, E. A., Slepukhin, P., Saloutin, V., & Bazhin, D. (2023). Exploring Three Avenues: Chemo- and Regioselective Transformations of 1,2,4-Triketone Analogs into Pyrazoles and Pyridazinones. International Journal of Molecular Sciences, 24(18), [14234]. https://doi.org/10.3390/ijms241814234apa_pure
dc.identifier.issn1661-6596-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access, Gold, Green3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85172930115&doi=10.3390%2fijms241814234&partnerID=40&md5=dc1fe14083277d15f1b0405eb58d0ad01
dc.identifier.otherhttps://www.mdpi.com/1422-0067/24/18/14234/pdf?version=1695036729pdf
dc.identifier.urihttp://elar.urfu.ru/handle/10995/130834-
dc.description.abstractA convenient approach to substituted pyrazoles and pyridazinones based on 1,2,4-triketones is presented. Chemo- and regiocontrol in condensations of t-Bu, Ph-, 2-thienyl-, and CO2Et-substituted 1,2,4-triketone analogs with hydrazines are described. The direction of preferential nucleophilic attack was shown to be switched depending on the substituent nature in triketone as well as the reaction conditions. The acid and temperature effects on the selectivity of condensations were revealed. Regiochemistry of heterocyclic core formation was confirmed by NMR and XRD studies. The facile construction of heterocyclic motifs bearing acetyl and (or) carbethoxy groups suggests them as promising mono- or bifunctional building blocks for subsequent transformations. © 2023 by the authors.en
dc.description.sponsorshipRussian Science Foundation, RSF: 23-23-00425en
dc.description.sponsorshipThis research was financially supported by the Russian Science Foundation (project no. 23-23-00425, https://rscf.ru/en/project/23-23-00425/), accessed on 1 August 2023.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.relationinfo:eu-repo/grantAgreement/RSF//23-23-00425en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightscc-byother
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/unpaywall
dc.sourceInternational Journal of Molecular Sciences2
dc.sourceInternational Journal of Molecular Sciencesen
dc.subject1,2,4-TRIKETONE ANALOGSen
dc.subjectBUILDING BLOCKSen
dc.subjectCHEMOSELECTIVITYen
dc.subjectPYRAZOLEen
dc.subjectPYRIDAZINEen
dc.subjectREGIOSELECTIVITYen
dc.subject1,2,4 TRIKETONE DERIVATIVEen
dc.subjectACETIC ACID DERIVATIVEen
dc.subjectACIDen
dc.subjectFUNCTIONAL GROUPen
dc.subjectKETONE DERIVATIVEen
dc.subjectPYRAZOLE DERIVATIVEen
dc.subjectPYRIDAZINONE DERIVATIVEen
dc.subjectUNCLASSIFIED DRUGen
dc.subjectARTICLEen
dc.subjectNUCLEAR MAGNETIC RESONANCEen
dc.subjectNUCLEOPHILICITYen
dc.subjectPOLYMERIZATIONen
dc.subjectREGIOSELECTIVITYen
dc.subjectSUBSTITUTION REACTIONen
dc.subjectTEMPERATURE SENSITIVITYen
dc.subjectX RAY DIFFRACTIONen
dc.titleExploring Three Avenues: Chemo- and Regioselective Transformations of 1,2,4-Triketone Analogs into Pyrazoles and Pyridazinonesen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.type|info:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3390/ijms241814234-
dc.identifier.scopus85172930115-
local.contributor.employeeEdilova, Y.O., Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeOsipova, E.A., Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federation, Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B.N. Eltsin, Yekaterinburg, 620002, Russian Federationen
local.contributor.employeeSlepukhin, P.A., Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeSaloutin, V.I., Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federationen
local.contributor.employeeBazhin, D.N., Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federation, Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B.N. Eltsin, Yekaterinburg, 620002, Russian Federationen
local.issue18-
local.volume24-
local.contributor.departmentPostovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, 620108, Russian Federationen
local.contributor.departmentDepartment of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B.N. Eltsin, Yekaterinburg, 620002, Russian Federationen
local.identifier.pure46011405-
local.description.order14234-
local.identifier.eid2-s2.0-85172930115-
local.fund.rsf23-23-00425-
local.identifier.pmid37762539-
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Files in This Item:
File Description SizeFormat 
2-s2.0-85172930115.pdf3,68 MBAdobe PDFView/Open
Show simple item record


This item is licensed under a Creative Commons License Creative Commons