Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic acids

Igidov, S. N.; Lipin, D. V.; Turyshev, A. Yu.; Chashchina, S. V.; Shipilovskikh, D. A.; Zvereva, O. V.; Mitusova, K. A.; Silaichev, P. S.; Igidov, N. M.

doi:10.15826/chimtech.2023.10.1.02

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/122147

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Igidov, S. N.	en
dc.contributor.author	Lipin, D. V.	en
dc.contributor.author	Turyshev, A. Yu.	en
dc.contributor.author	Chashchina, S. V.	en
dc.contributor.author	Shipilovskikh, D. A.	en
dc.contributor.author	Zvereva, O. V.	en
dc.contributor.author	Mitusova, K. A.	en
dc.contributor.author	Silaichev, P. S.	en
dc.contributor.author	Igidov, N. M.	en
dc.date.accessioned	2023-04-20T10:01:42Z	-
dc.date.available	2023-04-20T10:01:42Z	-
dc.date.issued	2023-03	-
dc.identifier.citation	Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic acids / S. N. Igidov, D. V. Lipin, A. Yu. Turyshev, S. V. Chashchina, Daria A. Shipilovskikh, O. V. Zvereva, K. A. Mitusova, P. S. Silaichev, N. M. Igidov // Chimica Techno Acta. — 2023. — Vol. 10, No. 1. — No. 202310102.	en
dc.identifier.issn	2411-1414	online
dc.identifier.uri	http://elar.urfu.ru/handle/10995/122147	-
dc.description	Received: 07.11.22. Revised: 08.12.22. Accepted: 08.12.22. Available online: 16.12.22.	en
dc.description	A synthesis method for obtained to produce methyl-2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids and N'-(2-oxofuran-3(2H)-ylidene]furan-2-carbohydrazides.	en
dc.description	Sixteen new biologically active compounds have been obtained and described.	en
dc.description	It was found that some of the compounds obtained have a significant anti-inflammatory effect.	en
dc.description.abstract	A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl) hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4- dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced antiinflammatory activity.	en
dc.description.sponsorship	This study was performed under financial support by the “Rational Use of the Earth Interior” Perm Scientific Educational Center 2023 and the Ministry of Science and Higher Education of the Russian Federation FSEG-2022-0012.	en
dc.language.iso	en	en
dc.publisher	Ural Federal University	en
dc.publisher	Уральский федеральный университет	ru
dc.relation.ispartof	Chimica Techno Acta. 2023. Vol. 10. № 1	en
dc.subject	DIOXOBUTANOIC ACIDS	en
dc.subject	2-HYDRAZONO-4-OXOBUTANOIC ACIDS	en
dc.subject	3-HYDRAZONOFURAN-2(3H)-ONES	en
dc.subject	ANTI-INFLAMMATORY ACTIVITY	en
dc.subject	DRUGS	en
dc.title	Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic acids	en
dc.type	Article	en
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.conference.name	MOSM2022	en
dc.conference.name	VI Международная конференция «Современные синтетические методологии для создания лекарственных препаратов и функциональных материалов»	ru
dc.conference.date	07.11.2022-11.11.2022	-
dc.identifier.rsi	https://www.elibrary.ru/item.asp?id=50757175	-
dc.identifier.doi	10.15826/chimtech.2023.10.1.02	-
local.issue	1	-
local.volume	10	-
local.contributor	Igidov, Sergei N.	en
local.contributor	Lipin, Dmitriy V.	en
local.contributor	Turyshev, Aleksey Yu.	en
local.contributor	Chashchina, Svetlana V.	en
local.contributor	Shipilovskikh, Daria A.	en
local.contributor	Zvereva, Ol’ga V.	en
local.contributor	Mitusova, Ksenia A.	en
local.contributor	Silaichev, Pavel S.	en
local.contributor	Igidov, Nazim M.	en
Располагается в коллекциях:	Chimica Techno Acta

Файлы этого ресурса:

Файл	Описание	Размер	Формат
cta-2023-1-02.pdf		468,03 kB	Adobe PDF	Просмотреть/Открыть

Показать базовое описание ресурса Статистика

Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.