Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/118323
Title: Scroll wave with negative filament tension in a model of the left ventricle of the human heart and its overdrive pacing
Authors: Pravdin, S. F.
Epanchintsev, T. I.
Dierckx, H.
Panfilov, A. V.
Issue Date: 2021
Publisher: American Physical Society
Citation: Scroll wave with negative filament tension in a model of the left ventricle of the human heart and its overdrive pacing / S. F. Pravdin, T. I. Epanchintsev, H. Dierckx et al. // Physical Review E. — 2021. — Vol. 104. — Iss. 3. — 34408.
Abstract: Nonlinear waves of electrical excitation initiate cardiac contraction. Abnormal wave propagation in the heart, e.g., spiral waves, can lead to sudden cardiac arrest. This study analyzed the dynamics of spiral waves under the influence of an instability called negative filament tension, and examined how the spiral waves can be eliminated through high-frequency pacing. A generic anatomical model of the left ventricle of the human heart and the Aliev-Panfilov model for cardiac tissue were used. The study showed that the source of such arrhythmia is elongated filaments with lengths that can be 10-20 times greater than the characteristic thickness of the heart wall. In anisotropic tissue, the filament elongated before it was annihilated at the base of the heart. The spiral waves were eliminated through overdrive pacing with stimulation periods from 0.8 to 0.95 relative to the spiral wave period. The minimum time for the expulsion was about 10 s. © 2021 American Physical Society.
Keywords: TISSUE
WAVE PROPAGATION
ALIEV-PANFILOV MODEL
ANATOMICAL MODELING
CARDIAC CONTRACTION
CHARACTERISTIC THICKNESS
ELECTRICAL EXCITATION
FILAMENT TENSION
HIGH FREQUENCY HF
SUDDEN CARDIAC ARREST
HEART
ANISOTROPY
BIOLOGICAL MODEL
HEART
HEART ARRHYTHMIA
HEART VENTRICLE
HUMAN
ANISOTROPY
ARRHYTHMIAS, CARDIAC
HEART
HEART VENTRICLES
HUMANS
MODELS, CARDIOVASCULAR
URI: http://hdl.handle.net/10995/118323
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85115188281
ISSN: 24700045
DOI: 10.1103/PhysRevE.104.034408
metadata.dc.description.sponsorship: Russian Science Foundation, RSF: 17-71-20024
Our work involved simulations at the “Uran” cluster of IMM UB RAS (Ekaterinburg). Our research is supported by a Russian Science Foundation grant (Project 17-71-20024).
RSCF project card: 17-71-20024
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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