Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

Korotina, A. V.; Tolshchina, S. G.; Ishmetova, R. I.; Evstigneeva, N. P.; Gerasimova, N. A.; Zilberberg, N. V.; Kungurov, N. V.; Rusinov, G. L.; Chupakhin, O. N.; Charushin, V. N.

doi:10.3762/bjoc.18.29

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Поле DC	Значение	Язык
dc.contributor.author	Korotina, A. V.	en
dc.contributor.author	Tolshchina, S. G.	en
dc.contributor.author	Ishmetova, R. I.	en
dc.contributor.author	Evstigneeva, N. P.	en
dc.contributor.author	Gerasimova, N. A.	en
dc.contributor.author	Zilberberg, N. V.	en
dc.contributor.author	Kungurov, N. V.	en
dc.contributor.author	Rusinov, G. L.	en
dc.contributor.author	Chupakhin, O. N.	en
dc.contributor.author	Charushin, V. N.	en
dc.date.accessioned	2022-10-19T05:22:38Z	-
dc.date.available	2022-10-19T05:22:38Z	-
dc.date.issued	2022	-
dc.identifier.citation	Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity / A. V. Korotina, S. G. Tolshchina, R. I. Ishmetova et al. // Beilstein Journal of Organic Chemistry. — 2022. — Vol. 18. — P. 243-250.	en
dc.identifier.issn	18605397	-
dc.identifier.other	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128396407&doi=10.3762%2fbjoc.18.29&partnerID=40&md5=66f471deb9801f1555b6d5758f5b4628	link
dc.identifier.uri	http://elar.urfu.ru/handle/10995/118131	-
dc.description.abstract	A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments. It is shown that the heterocyclic systems obtained can be modified easily at C(3) position in the reactions with aliphatic alcohols and amines. Also, the reactivity of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines towards CH-active compounds has been studied. The obtained triazolo[1,5-b]annulated 1,2,4,5-tetrazines proved to be active in micromolar concentrations in vitro against filamentous anthropophilic and zooanthropophilic dermatophyte fungi (Trichophyton, Microsporum and Epidermofiton), which cause skin and its appendages (hair, nails) diseases. © 2022 Korotina et al.; licensee Beilstein-Institut.	en
dc.description.sponsorship	Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-777; Ural Branch, Russian Academy of Sciences, UB RAS	en
dc.description.sponsorship	This work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777).	en
dc.description.sponsorship	Analytical studies were carried out using equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds”, located in Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences. This work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777).	en
dc.format.mimetype	application/pdf	en
dc.language.iso	en	en
dc.publisher	Beilstein-Institut Zur Forderung der Chemischen Wissenschaften	en
dc.rights	info:eu-repo/semantics/openAccess	en
dc.source	Beilstein Journal of Organic Chemistry	en
dc.subject	ANTIFUNGAL ACTIVITY	en
dc.subject	NUCLEOPHILIC SUBSTITUTION	en
dc.subject	OXIDATIVE CYCLIZATION	en
dc.title	Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity	en
dc.type	Article	en
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.identifier.doi	10.3762/bjoc.18.29	-
dc.identifier.scopus	85128396407	-
local.contributor.employee	Korotina, A.V., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation	en
local.contributor.employee	Tolshchina, S.G., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation	en
local.contributor.employee	Ishmetova, R.I., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation	en
local.contributor.employee	Evstigneeva, N.P., Experimental Laboratory Department, Ural Research Institute of Dermatovenerology and Immunopathology, Shcherbakova str. 8, Yekaterinburg, 620076, Russian Federation	en
local.contributor.employee	Gerasimova, N.A., Experimental Laboratory Department, Ural Research Institute of Dermatovenerology and Immunopathology, Shcherbakova str. 8, Yekaterinburg, 620076, Russian Federation	en
local.contributor.employee	Zilberberg, N.V., Experimental Laboratory Department, Ural Research Institute of Dermatovenerology and Immunopathology, Shcherbakova str. 8, Yekaterinburg, 620076, Russian Federation	en
local.contributor.employee	Kungurov, N.V., Experimental Laboratory Department, Ural Research Institute of Dermatovenerology and Immunopathology, Shcherbakova str. 8, Yekaterinburg, 620076, Russian Federation	en
local.contributor.employee	Rusinov, G.L., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation, Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, Mira str. 19, Yekaterinburg, 620002, Russian Federation	en
local.contributor.employee	Chupakhin, O.N., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation, Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, Mira str. 19, Yekaterinburg, 620002, Russian Federation	en
local.contributor.employee	Charushin, V.N., Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation, Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, Mira str. 19, Yekaterinburg, 620002, Russian Federation	en
local.description.firstpage	243	-
local.description.lastpage	250	-
local.volume	18	-
dc.identifier.wos	000767283000001	-
local.contributor.department	Laboratory of Heterocyclic Compounds, Postovsky Institute of Organic Synthesis, Russian Academy of Sciences, Ural Branch, S. Kovalevskaya str. 22/20, Yekaterinburg, 620108, Russian Federation	en
local.contributor.department	Experimental Laboratory Department, Ural Research Institute of Dermatovenerology and Immunopathology, Shcherbakova str. 8, Yekaterinburg, 620076, Russian Federation	en
local.contributor.department	Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, Mira str. 19, Yekaterinburg, 620002, Russian Federation	en
local.identifier.pure	29832560	-
local.identifier.eid	2-s2.0-85128396407	-
local.identifier.wos	WOS:000767283000001	-
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