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http://elar.urfu.ru/handle/10995/117975
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DC Field | Value | Language |
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dc.contributor.author | Gusev, V. V. | en |
dc.contributor.author | Kovtun, O. P. | en |
dc.contributor.author | Lvova, O. A. | en |
dc.contributor.author | Partylova, E. A. | en |
dc.contributor.author | Sergeev, A. P. | en |
dc.contributor.author | Sergeeva, M. V. | en |
dc.contributor.author | Yanchuk, I. T. | en |
dc.contributor.author | Dobrazova, D. A. | en |
dc.contributor.author | Suvorkov, P. A. | en |
dc.contributor.author | Shamalov, N. A. | en |
dc.date.accessioned | 2022-10-19T05:20:55Z | - |
dc.date.available | 2022-10-19T05:20:55Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients / V. V. Gusev, O. P. Kovtun, O. A. Lvova et al. // Nevrologiya, Neiropsikhiatriya, Psikhosomatika. — 2022. — Vol. 14. — Iss. 3. — P. 12-18. | en |
dc.identifier.issn | 20742711 | - |
dc.identifier.other | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133840987&doi=10.14412%2f2074-2711-2022-3-12-18&partnerID=40&md5=5152e40847154e4cf4f307fd618cbfd1 | link |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/117975 | - |
dc.description.abstract | Objective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients. Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G. Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients. Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms. © 2022 Ima-Press Publishing House. All rights reserved. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | Ima-Press Publishing House | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | Nevrologiya, Neiropsikhiatriya, Psikhosomatika | en |
dc.subject | ISCHEMIC STROKE | en |
dc.subject | RISK FACTORS | en |
dc.subject | SINGLE NUCLEOTIDE SUBSTITUTIONS | en |
dc.subject | THROMBOPHILIA | en |
dc.subject | YOUNG AGE | en |
dc.subject | ALPHA2 INTEGRIN | en |
dc.subject | BETA3 INTEGRIN | en |
dc.subject | BLOOD CLOTTING FACTOR 5 | en |
dc.subject | BLOOD CLOTTING FACTOR 7 | en |
dc.subject | FIBRINOGEN | en |
dc.subject | FIBRINOGEN BETA | en |
dc.subject | PLASMINOGEN ACTIVATOR INHIBITOR 1 | en |
dc.subject | UNCLASSIFIED DRUG | en |
dc.subject | ADULT | en |
dc.subject | ANAMNESIS | en |
dc.subject | ARTICLE | en |
dc.subject | ATHEROSCLEROTIC PLAQUE | en |
dc.subject | ATRIAL FIBRILLATION | en |
dc.subject | BRACHIOCEPHALIC ARTERY STENOSIS | en |
dc.subject | BRAIN INFARCTION | en |
dc.subject | BRAIN VASCULITIS | en |
dc.subject | CEREBROVASCULAR MALFORMATION | en |
dc.subject | CLINICAL FEATURE | en |
dc.subject | COHORT ANALYSIS | en |
dc.subject | COMPUTER ASSISTED TOMOGRAPHY | en |
dc.subject | CONTROLLED STUDY | en |
dc.subject | DNA POLYMORPHISM | en |
dc.subject | DYSLIPOPROTEINEMIA | en |
dc.subject | ERYTHROCYTE SEDIMENTATION RATE | en |
dc.subject | FEMALE | en |
dc.subject | GENETIC PREDISPOSITION | en |
dc.subject | GENETIC VARIABILITY | en |
dc.subject | HEART LEFT VENTRICLE HYPERTROPHY | en |
dc.subject | HETEROZYGOTE | en |
dc.subject | HOSPITAL ADMISSION | en |
dc.subject | HOSPITALIZATION | en |
dc.subject | HUMAN | en |
dc.subject | HYPERLIPIDEMIA | en |
dc.subject | INTENSIVE CARE | en |
dc.subject | ISCHEMIC STROKE | en |
dc.subject | MAJOR CLINICAL STUDY | en |
dc.subject | MALE | en |
dc.subject | METABOLIC DISORDER | en |
dc.subject | MIGRAINE | en |
dc.subject | MITRAL VALVE PROLAPSE | en |
dc.subject | NUCLEAR MAGNETIC RESONANCE IMAGING | en |
dc.subject | NUCLEIC ACID BASE SUBSTITUTION | en |
dc.subject | OCCLUSIVE CEREBROVASCULAR DISEASE | en |
dc.subject | PARALYSIS | en |
dc.subject | PARESIS | en |
dc.subject | RANKIN SCALE | en |
dc.subject | RISK FACTOR | en |
dc.subject | SELF CARE | en |
dc.subject | SPEECH DISORDER | en |
dc.subject | THROMBOPHILIA | en |
dc.title | Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.14412/2074-2711-2022-3-12-18 | - |
dc.identifier.scopus | 85133840987 | - |
local.contributor.employee | Gusev, V.V., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation, Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation, Central City Clinical Hospital № 23, 9, Starikh Bolshevikov St., Yekaterinburg, 620017, Russian Federation | en |
local.contributor.employee | Kovtun, O.P., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation | en |
local.contributor.employee | Lvova, O.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation, Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation | en |
local.contributor.employee | Partylova, E.A., Sverdlovskaya Regional Clinical Hospital № 1, 185, Volgogradskaya St., Yekaterinburg, 620102, Russian Federation | en |
local.contributor.employee | Sergeev, A.P., Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation, Institute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federation | en |
local.contributor.employee | Sergeeva, M.V., Institute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federation | en |
local.contributor.employee | Yanchuk, I.T., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation | en |
local.contributor.employee | Dobrazova, D.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation | en |
local.contributor.employee | Suvorkov, P.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation | en |
local.contributor.employee | Shamalov, N.A., Research Institute of Cerebrovascular Pathology and Stroke, Federal Center for Brain and Neurotechnologies of Federal Medical and Biological Agency, 1, Ostrovityanova St., Build. 1, Moscow, 117513, Russian Federation | en |
local.description.firstpage | 12 | - |
local.description.lastpage | 18 | - |
local.issue | 3 | - |
local.volume | 14 | - |
local.contributor.department | Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation | en |
local.contributor.department | Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation | en |
local.contributor.department | Central City Clinical Hospital № 23, 9, Starikh Bolshevikov St., Yekaterinburg, 620017, Russian Federation | en |
local.contributor.department | Research Institute of Cerebrovascular Pathology and Stroke, Federal Center for Brain and Neurotechnologies of Federal Medical and Biological Agency, 1, Ostrovityanova St., Build. 1, Moscow, 117513, Russian Federation | en |
local.contributor.department | Sverdlovskaya Regional Clinical Hospital № 1, 185, Volgogradskaya St., Yekaterinburg, 620102, Russian Federation | en |
local.contributor.department | Institute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federation | en |
local.identifier.pure | 30625889 | - |
local.identifier.eid | 2-s2.0-85133840987 | - |
Appears in Collections: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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2-s2.0-85133840987.pdf | 122,56 kB | Adobe PDF | View/Open |
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