Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/117975
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dc.contributor.authorGusev, V. V.en
dc.contributor.authorKovtun, O. P.en
dc.contributor.authorLvova, O. A.en
dc.contributor.authorPartylova, E. A.en
dc.contributor.authorSergeev, A. P.en
dc.contributor.authorSergeeva, M. V.en
dc.contributor.authorYanchuk, I. T.en
dc.contributor.authorDobrazova, D. A.en
dc.contributor.authorSuvorkov, P. A.en
dc.contributor.authorShamalov, N. A.en
dc.date.accessioned2022-10-19T05:20:55Z-
dc.date.available2022-10-19T05:20:55Z-
dc.date.issued2022-
dc.identifier.citationAnamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients / V. V. Gusev, O. P. Kovtun, O. A. Lvova et al. // Nevrologiya, Neiropsikhiatriya, Psikhosomatika. — 2022. — Vol. 14. — Iss. 3. — P. 12-18.en
dc.identifier.issn20742711-
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85133840987&doi=10.14412%2f2074-2711-2022-3-12-18&partnerID=40&md5=5152e40847154e4cf4f307fd618cbfd1link
dc.identifier.urihttp://elar.urfu.ru/handle/10995/117975-
dc.description.abstractObjective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients. Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G. Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients. Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms. © 2022 Ima-Press Publishing House. All rights reserved.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherIma-Press Publishing Houseen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceNevrologiya, Neiropsikhiatriya, Psikhosomatikaen
dc.subjectISCHEMIC STROKEen
dc.subjectRISK FACTORSen
dc.subjectSINGLE NUCLEOTIDE SUBSTITUTIONSen
dc.subjectTHROMBOPHILIAen
dc.subjectYOUNG AGEen
dc.subjectALPHA2 INTEGRINen
dc.subjectBETA3 INTEGRINen
dc.subjectBLOOD CLOTTING FACTOR 5en
dc.subjectBLOOD CLOTTING FACTOR 7en
dc.subjectFIBRINOGENen
dc.subjectFIBRINOGEN BETAen
dc.subjectPLASMINOGEN ACTIVATOR INHIBITOR 1en
dc.subjectUNCLASSIFIED DRUGen
dc.subjectADULTen
dc.subjectANAMNESISen
dc.subjectARTICLEen
dc.subjectATHEROSCLEROTIC PLAQUEen
dc.subjectATRIAL FIBRILLATIONen
dc.subjectBRACHIOCEPHALIC ARTERY STENOSISen
dc.subjectBRAIN INFARCTIONen
dc.subjectBRAIN VASCULITISen
dc.subjectCEREBROVASCULAR MALFORMATIONen
dc.subjectCLINICAL FEATUREen
dc.subjectCOHORT ANALYSISen
dc.subjectCOMPUTER ASSISTED TOMOGRAPHYen
dc.subjectCONTROLLED STUDYen
dc.subjectDNA POLYMORPHISMen
dc.subjectDYSLIPOPROTEINEMIAen
dc.subjectERYTHROCYTE SEDIMENTATION RATEen
dc.subjectFEMALEen
dc.subjectGENETIC PREDISPOSITIONen
dc.subjectGENETIC VARIABILITYen
dc.subjectHEART LEFT VENTRICLE HYPERTROPHYen
dc.subjectHETEROZYGOTEen
dc.subjectHOSPITAL ADMISSIONen
dc.subjectHOSPITALIZATIONen
dc.subjectHUMANen
dc.subjectHYPERLIPIDEMIAen
dc.subjectINTENSIVE CAREen
dc.subjectISCHEMIC STROKEen
dc.subjectMAJOR CLINICAL STUDYen
dc.subjectMALEen
dc.subjectMETABOLIC DISORDERen
dc.subjectMIGRAINEen
dc.subjectMITRAL VALVE PROLAPSEen
dc.subjectNUCLEAR MAGNETIC RESONANCE IMAGINGen
dc.subjectNUCLEIC ACID BASE SUBSTITUTIONen
dc.subjectOCCLUSIVE CEREBROVASCULAR DISEASEen
dc.subjectPARALYSISen
dc.subjectPARESISen
dc.subjectRANKIN SCALEen
dc.subjectRISK FACTORen
dc.subjectSELF CAREen
dc.subjectSPEECH DISORDERen
dc.subjectTHROMBOPHILIAen
dc.titleAnamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patientsen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.14412/2074-2711-2022-3-12-18-
dc.identifier.scopus85133840987-
local.contributor.employeeGusev, V.V., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation, Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation, Central City Clinical Hospital № 23, 9, Starikh Bolshevikov St., Yekaterinburg, 620017, Russian Federationen
local.contributor.employeeKovtun, O.P., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federationen
local.contributor.employeeLvova, O.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federation, Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federationen
local.contributor.employeePartylova, E.A., Sverdlovskaya Regional Clinical Hospital № 1, 185, Volgogradskaya St., Yekaterinburg, 620102, Russian Federationen
local.contributor.employeeSergeev, A.P., Ural Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federation, Institute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federationen
local.contributor.employeeSergeeva, M.V., Institute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federationen
local.contributor.employeeYanchuk, I.T., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federationen
local.contributor.employeeDobrazova, D.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federationen
local.contributor.employeeSuvorkov, P.A., Ural State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federationen
local.contributor.employeeShamalov, N.A., Research Institute of Cerebrovascular Pathology and Stroke, Federal Center for Brain and Neurotechnologies of Federal Medical and Biological Agency, 1, Ostrovityanova St., Build. 1, Moscow, 117513, Russian Federationen
local.description.firstpage12-
local.description.lastpage18-
local.issue3-
local.volume14-
local.contributor.departmentUral State Medical University, Ministry of Health of Russia, 3, Repina St., Yekaterinburg, 620028, Russian Federationen
local.contributor.departmentUral Federal University named after the first President of Russia B.N.Yeltsin, 19, Mira St., Yekaterinburg, 620002, Russian Federationen
local.contributor.departmentCentral City Clinical Hospital № 23, 9, Starikh Bolshevikov St., Yekaterinburg, 620017, Russian Federationen
local.contributor.departmentResearch Institute of Cerebrovascular Pathology and Stroke, Federal Center for Brain and Neurotechnologies of Federal Medical and Biological Agency, 1, Ostrovityanova St., Build. 1, Moscow, 117513, Russian Federationen
local.contributor.departmentSverdlovskaya Regional Clinical Hospital № 1, 185, Volgogradskaya St., Yekaterinburg, 620102, Russian Federationen
local.contributor.departmentInstitute of Industrial Ecology, Ural Branch of Russian Academy of Science, 20, S. Kovalevskoy St., Yekaterinburg, 620990, Russian Federationen
local.identifier.pure30625889-
local.identifier.eid2-s2.0-85133840987-
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