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Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/117964
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dc.contributor.authorKrasnov, V. P.en
dc.contributor.authorMusiyak, V. V.en
dc.contributor.authorLevit, G. L.en
dc.contributor.authorGruzdev, D. A.en
dc.contributor.authorAndronova, V. L.en
dc.contributor.authorGalegov, G. A.en
dc.contributor.authorOrshanskaya, I. R.en
dc.contributor.authorSinegubova, E. O.en
dc.contributor.authorZarubaev, V. V.en
dc.contributor.authorCharushin, V. N.en
dc.date.accessioned2022-10-19T05:20:50Z-
dc.date.available2022-10-19T05:20:50Z-
dc.date.issued2022-
dc.identifier.citationSynthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4] benzoxazine and Evaluation of Their Antiviral Activity / V. P. Krasnov, V. V. Musiyak, G. L. Levit et al. // Molecules. — 2022. — Vol. 27. — Iss. 13. — 4236.en
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85133468546&doi=10.3390%2fmolecules27134236&partnerID=40&md5=d2789101d0a6e7aa7a5c5f52b7c82df4link
dc.identifier.urihttp://elar.urfu.ru/handle/10995/117964-
dc.description.abstractA series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. The structures of the synthesized compounds were confirmed by1H,19F, and 13 C NMR spectral data. Enantiomeric purity of optically active derivatives was confirmed by chiral HPLC. Antiviral evaluation of the synthesized compounds has shown that the replacement of purine with a pyrimidine fragment leads to a decrease in the anti-herpesvirus activity compared to the lead compound, purine conjugate. The studied compounds did not exhibit significant activity against influenza A (H1N1) virus. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.sponsorshipRussian Science Foundation, RSF: 19-13-00231-Pen
dc.description.sponsorshipFunding: This research was funded by the Russian Science Foundation, grant number 19-13-00231-P.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/RSF//19-13-00231en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceMoleculesen
dc.subject7,8-DIFLUORO-3,4-DIHYDRO-3-METHYL-2H-[1,4]BENZOXAZINEen
dc.subjectANTIVIRAL ACTIVITYen
dc.subjectHSV-1en
dc.subjectINFLUENZA VIRUSen
dc.subjectPURINEen
dc.subjectPYRIMIDINEen
dc.subjectANTIVIRUS AGENTen
dc.subjectBENZOXAZINE DERIVATIVEen
dc.subjectPURINE DERIVATIVEen
dc.subjectPYRIMIDINE DERIVATIVEen
dc.subjectCHEMISTRYen
dc.subjectINFLUENZA A VIRUSen
dc.subjectINFLUENZA A VIRUS (H1N1)en
dc.subjectANTIVIRAL AGENTSen
dc.subjectBENZOXAZINESen
dc.subjectINFLUENZA A VIRUSen
dc.subjectINFLUENZA A VIRUS, H1N1 SUBTYPEen
dc.subjectPURINESen
dc.subjectPYRIMIDINESen
dc.titleSynthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4] benzoxazine and Evaluation of Their Antiviral Activityen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3390/molecules27134236-
dc.identifier.scopus85133468546-
local.contributor.employeeKrasnov, V.P., Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federationen
local.contributor.employeeMusiyak, V.V., Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federation, Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, 620002, Russian Federationen
local.contributor.employeeLevit, G.L., Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federationen
local.contributor.employeeGruzdev, D.A., Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federationen
local.contributor.employeeAndronova, V.L., Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, 123098, Russian Federationen
local.contributor.employeeGalegov, G.A., Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, 123098, Russian Federationen
local.contributor.employeeOrshanskaya, I.R., Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, 197101, Russian Federationen
local.contributor.employeeSinegubova, E.O., Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, 197101, Russian Federationen
local.contributor.employeeZarubaev, V.V., Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, 197101, Russian Federationen
local.contributor.employeeCharushin, V.N., Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federation, Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, 620002, Russian Federationen
local.issue13-
local.volume27-
dc.identifier.wos000823880500001-
local.contributor.departmentPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg, 620108, Russian Federationen
local.contributor.departmentInstitute of Chemical Engineering, Ural Federal University, Ekaterinburg, 620002, Russian Federationen
local.contributor.departmentIvanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, 123098, Russian Federationen
local.contributor.departmentSaint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, 197101, Russian Federationen
local.identifier.pure30530066-
local.description.order4236-
local.identifier.eid2-s2.0-85133468546-
local.fund.rsf19-13-00231-
local.identifier.wosWOS:000823880500001-
local.identifier.pmid14203049-
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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