PEG-4000 Increases Solubility and Dissolution Rate of Vinpocetin in Solid Dispersion System

Abstract

In the present work, we determined the optimal ratio of vinpocetine and polyethylene glycol within a solid dispersion (1:2 or 1:5) according to the simulation results in the framework of molecular dynamics associated with the release of the reactant into aqueous medium. For the simulation of vinpocetine release from its alloy with polyethylene glycol, a technique of coarse-grained molecular dynamics in the force field of Martini 2.2 was applied using the Gromacs 2018 computer program. The results of the simulation demonstrated that at pH 6.8 polyethylene glycol facilitated vinpocetine solubilization and thus considerably enhanced its solubility in water. The data obtained show that the values of the energies of van der Waals interaction between vinpocetine and the polymer are similar to those vinpocetine and water, both at a ratio of 1:2 and at a ratio of 1:5.