Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/112178
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dc.contributor.authorRokeakh, R.en
dc.contributor.authorNesterova, T.en
dc.contributor.authorUshenin, K.en
dc.contributor.authorPolyakova, E.en
dc.contributor.authorSonin, D.en
dc.contributor.authorGalagudza, M.en
dc.contributor.authorDe Coster, T.en
dc.contributor.authorPanfilov, A.en
dc.contributor.authorSolovyova, O.en
dc.date.accessioned2022-05-12T08:30:04Z-
dc.date.available2022-05-12T08:30:04Z-
dc.date.issued2021-
dc.identifier.citationAnatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury / R. Rokeakh, T. Nesterova, K. Ushenin et al. // Mathematics. — 2021. — Vol. 9. — Iss. 20. — 2604.en
dc.identifier.issn2227-7390-
dc.identifier.otherAll Open Access, Gold3
dc.identifier.urihttp://elar.urfu.ru/handle/10995/112178-
dc.description.abstractSpecies-specific computer models of the heart are a novel powerful tool in studies of life-threatening cardiac arrhythmias. Here, we develop such a model aimed at studying infarction injury in a rat heart, the most common experimental system to investigate the effects of myocardial damage. We updated the Gattoni2016 cellular ionic model by fitting its parameters to experimental data using a population modeling approach. Using four selected cellular models, we studied 2D spiral wave dynamics and found that they include meandering and break-up. Then, using an anatomically realistic ventricular geometry and fiber orientation in the rat heart, we built a model with a postinfarction scar to study the electrophysiological effects of myocardial damage. A post-infarction scar was simulated as an inexcitable obstacle surrounded by a border zone with modified cardiomyocyte properties. For cellular models, we studied the rotation of scroll waves and found that, depending on the model, we can observe different types of dynamics: anchoring, self-termination or stable rotation of the scroll wave. The observed arrhythmia characteristics coincide with those measured in the experiment. The developed model can be used to study arrhythmia in rat hearts with myocardial damage from ischemia reperfusion and to examine the possible arrhythmogenic effects of various experimental interventions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.sponsorshipThis study has been supported by a grant from the Ministry of Science and Higher Education of the Russian Federation (agreement № 075-15-2020-800).en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen1
dc.publisherMDPI AGen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceMathematics2
dc.sourceMathematicsen
dc.subjectCARDIAC MODELINGen
dc.subjectCARDIAC SIMULATIONen
dc.subjectISCHEMIAen
dc.subjectMYOCARDIAL INFARCTIONen
dc.subjectPOST-INFARCTION SCARen
dc.subjectRAT HEARTen
dc.subjectVENTRICULAR ARRHYTHMIAen
dc.titleAnatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injuryen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.rsi47514962-
dc.identifier.doi10.3390/math9202604-
dc.identifier.scopus85117438794-
local.contributor.employeeRokeakh, R., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation, Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, 620049, Russian Federation, Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federation; Nesterova, T., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation, Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, 620049, Russian Federation, Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federation; Ushenin, K., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, 620049, Russian Federation, Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federation; Polyakova, E., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation; Sonin, D., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation; Galagudza, M., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation; De Coster, T., Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands; Panfilov, A., Almazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation, Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federation, Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands, Department of Physics and Astronomy, Ghent University, Krijgslaan 281, Gent, 9000, Belgium; Solovyova, O., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, 620049, Russian Federation, Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federationen
local.issue20-
local.volume9-
dc.identifier.wos000716389900001-
local.contributor.departmentAlmazov National Medical Research Centre, Saint-Petersburg, 197341, Russian Federation; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, 620049, Russian Federation; Institute of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg, 620075, Russian Federation; Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands; Department of Physics and Astronomy, Ghent University, Krijgslaan 281, Gent, 9000, Belgiumen
local.identifier.pure23897290-
local.description.order2604-
local.identifier.eid2-s2.0-85117438794-
local.identifier.wosWOS:000716389900001-
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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