Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111958
Title: Origin and Distribution of Tick-Borne Encephalitis Virus Strains of the Siberian Subtype in the Middle Urals, the North-West of Russia and the Baltic Countries
Authors: Kovalev, S. Yu.
Chernykh, D. N.
Kokorev, V. S.
Snitkovskaya, T. E.
Romanenko, V. V.
Issue Date: 2009
Publisher: Microbiology Society
Citation: Origin and Distribution of Tick-Borne Encephalitis Virus Strains of the Siberian Subtype in the Middle Urals, the North-West of Russia and the Baltic Countries / S. Yu. Kovalev, D. N. Chernykh, V. S. Kokorev et al. // Journal of General Virology. — 2009. — Vol. 90. — Iss. 12. — P. 2884-2892.
Abstract: Tick-borne encephalitis virus (TBEV) plays an important role in infectious human morbidity, particularly in Russia and the Middle Urals. The Siberian subtype of TBEV (S-TBEV) is dominant in the Middle Urals. Determining the origin of S-TBEV strains in this territory and also in the European part of Russia and the Baltic countries is very important for understanding the cause of its distribution. The surface glycoprotein E gene was partially sequenced in 165 S-TBEV isolates collected in the Middle Urals between 1966 and 2008. Nucleotide and amino acid sequence identity of the studied isolates is 94 and 97.4 %, respectively. Eighty per cent of them are represented by six clusters with identical amino acid sequences in the glycoprotein E fragment analysed. We have determined four types of isolate distribution in the explored territory: local, split, corridor and diffuse. The average rate of nucleotide substitutions per site year-1 is estimated to be 1.56×10-4. The age of the S-TBEV population was evaluated to be slightly less than 400 years. Phylogenetic analysis of the data and comparison with historical events indicate that the distribution of S-TBEV strains in the Middle Urals and the European part of Russia originated twice from different foci in western Siberia. This is related to the first land road into Siberia and the Trans-Siberian Way, which functioned at different times. The main reason for such rapid distribution of S-TBEV strains is the anthropogenic factor, i.e. human economic activity during the colonization of new territories in Siberia in the recent past. © 2009 SGM.
Keywords: GLYCOPROTEIN E
AMINO ACID SEQUENCE
ARTICLE
BALTIC STATES
CONTROLLED STUDY
GENE AMPLIFICATION
GENE CLUSTER
GENETIC VARIABILITY
GEOGRAPHIC DISTRIBUTION
NONHUMAN
NUCLEOTIDE SEQUENCE
OPEN READING FRAME
PHYLOGENETIC TREE
PHYLOGENY
PRIORITY JOURNAL
RUSSIAN FEDERATION
TICK BORNE ENCEPHALITIS FLAVIVIRUS
UNINDEXED SEQUENCE
VIRUS STRAIN
AMINO ACID SEQUENCE
ANIMALS
BALTIC STATES
ENCEPHALITIS VIRUSES, TICK-BORNE
ENCEPHALITIS, TICK-BORNE
EVOLUTION, MOLECULAR
HUMANS
PHYLOGENY
POLYMERASE CHAIN REACTION
RUSSIA
SEQUENCE ANALYSIS, DNA
SIBERIA
VIRAL ENVELOPE PROTEINS
TICK-BORNE ENCEPHALITIS VIRUS
URI: http://hdl.handle.net/10995/111958
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 70849106288
ISSN: 0022-1317
metadata.dc.description.sponsorship: We are indebted to Dr Irina Belyaeva (Royal Botanic Gardens, Kew, UK) and Dr Keith Chamberlain (Rothamsted Reseach, Harpenden, UK) for their help in preparing the manuscript. We thank Tatyana Pimenova and Boris Galishev for their help in tick collecting. This project was supported by the Russian Foundation of Fundamental Research (no. 07-04-96115).
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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