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http://elar.urfu.ru/handle/10995/111882
Название: | Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy |
Авторы: | Korolkov, I. V. Zibert, A. V. Lissovskaya, L. I. Ludzik, K. Anisovich, M. Kozlovskiy, A. L. Shumskaya, A. E. Vasilyeva, M. Shlimas, D. I. Jażdżewska, M. Marciniak, B. Kontek, R. Chudoba, D. Zdorovets, M. V. |
Дата публикации: | 2021 |
Издатель: | MDPI AG MDPI AG |
Библиографическое описание: | Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy / I. V. Korolkov, A. V. Zibert, L. I. Lissovskaya et al. // International Journal of Molecular Sciences. — 2021. — Vol. 22. — Iss. 16. — 8687. |
Аннотация: | In this article, a novel method of simultaneous carborane-and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for fur-ther immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, mor-phology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Ключевые слова: | CARBORANE CYTOTOXICITY GADOLINIUM NCT SUPERPARAMAGNETIC FE3O4 NANOPARTICLES TARGETED DRUG DELIVERY BORON GADOLINIUM MAGNETITE NANOPARTICLE BORON NEUTRON CAPTURE THERAPY CELL PROLIFERATION CELL SURVIVAL CHEMISTRY HUMAN INFRARED SPECTROSCOPY MCF-7 CELL LINE PARTICLE SIZE PHOTON CORRELATION SPECTROSCOPY PROCEDURES RADIATION RESPONSE SCANNING ELECTRON MICROSCOPY TUMOR CELL LINE X RAY DIFFRACTION BORON BORON NEUTRON CAPTURE THERAPY CELL LINE, TUMOR CELL PROLIFERATION CELL SURVIVAL DYNAMIC LIGHT SCATTERING GADOLINIUM HUMANS MAGNETITE NANOPARTICLES MCF-7 CELLS MICROSCOPY, ELECTRON, SCANNING PARTICLE SIZE PC-3 CELLS SPECTROSCOPY, FOURIER TRANSFORM INFRARED X-RAY DIFFRACTION |
URI: | http://elar.urfu.ru/handle/10995/111882 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор SCOPUS: | 85112376680 |
Идентификатор WOS: | 000690447600001 |
Идентификатор PURE: | 22979669 |
ISSN: | 1661-6596 |
DOI: | 10.3390/ijms22168687 |
Сведения о поддержке: | This study was funded by the Ministry of Education and Science of the Republic of Kazakhstan (grant No. AP08051954 "Synthesis and modification of magnetic nanoparticles for targeted delivery of drugs"), Joint Institute for Nuclear Research-Republic of Kazakhstan cooperation program (Order No. 391, 20 July 2020) and grant №M20MC-024 of The Belarusian Republican Foundation for Fundamental Research. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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Файл | Описание | Размер | Формат | |
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2-s2.0-85112376680.pdf | 3,46 MB | Adobe PDF | Просмотреть/Открыть |
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