Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111882
Title: Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy
Authors: Korolkov, I. V.
Zibert, A. V.
Lissovskaya, L. I.
Ludzik, K.
Anisovich, M.
Kozlovskiy, A. L.
Shumskaya, A. E.
Vasilyeva, M.
Shlimas, D. I.
Jażdżewska, M.
Marciniak, B.
Kontek, R.
Chudoba, D.
Zdorovets, M. V.
Issue Date: 2021
Publisher: MDPI AG
MDPI AG
Citation: Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy / I. V. Korolkov, A. V. Zibert, L. I. Lissovskaya et al. // International Journal of Molecular Sciences. — 2021. — Vol. 22. — Iss. 16. — 8687.
Abstract: In this article, a novel method of simultaneous carborane-and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for fur-ther immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, mor-phology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: CARBORANE
CYTOTOXICITY
GADOLINIUM
NCT
SUPERPARAMAGNETIC FE3O4 NANOPARTICLES
TARGETED DRUG DELIVERY
BORON
GADOLINIUM
MAGNETITE NANOPARTICLE
BORON NEUTRON CAPTURE THERAPY
CELL PROLIFERATION
CELL SURVIVAL
CHEMISTRY
HUMAN
INFRARED SPECTROSCOPY
MCF-7 CELL LINE
PARTICLE SIZE
PHOTON CORRELATION SPECTROSCOPY
PROCEDURES
RADIATION RESPONSE
SCANNING ELECTRON MICROSCOPY
TUMOR CELL LINE
X RAY DIFFRACTION
BORON
BORON NEUTRON CAPTURE THERAPY
CELL LINE, TUMOR
CELL PROLIFERATION
CELL SURVIVAL
DYNAMIC LIGHT SCATTERING
GADOLINIUM
HUMANS
MAGNETITE NANOPARTICLES
MCF-7 CELLS
MICROSCOPY, ELECTRON, SCANNING
PARTICLE SIZE
PC-3 CELLS
SPECTROSCOPY, FOURIER TRANSFORM INFRARED
X-RAY DIFFRACTION
URI: http://hdl.handle.net/10995/111882
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85112376680
PURE ID: 22979669
ISSN: 1661-6596
metadata.dc.description.sponsorship: This study was funded by the Ministry of Education and Science of the Republic of Kazakhstan (grant No. AP08051954 "Synthesis and modification of magnetic nanoparticles for targeted delivery of drugs"), Joint Institute for Nuclear Research-Republic of Kazakhstan cooperation program (Order No. 391, 20 July 2020) and grant №M20MC-024 of The Belarusian Republican Foundation for Fundamental Research.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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