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|Title:||Synthesis and Characterization of a Novel Biocompatible Alloy, ti-nb-zr-ta-sn|
|Authors:||Khrunyk, Y. Y.|
Grib, S. V.
Illarionov, A. G.
Stepanov, S. I.
Popov, A. A.
Ryzhkov, M. A.
Belikov, S. V.
Nüssler, A. K.
|Citation:||Synthesis and Characterization of a Novel Biocompatible Alloy, ti-nb-zr-ta-sn / Y. Y. Khrunyk, S. Ehnert, S. V. Grib et al. // International Journal of Molecular Sciences. — 2021. — Vol. 22. — Iss. 19. — 10611.|
|Abstract:||Many current-generation biomedical implants are fabricated from the Ti-6Al-4V alloy because it has many attractive properties, such as low density and biocompatibility. However, the elastic modulus of this alloy is much larger than that of the surrounding bone, leading to bone resorption and, eventually, implant failure. In the present study, we synthesized and performed a detailed analysis of a novel low elastic modulus Ti-based alloy (Ti-28Nb-5Zr-2Ta-2Sn (TNZTS alloy)) using a variety of methods, including scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile test. Additionally, the in vitro biocompatibility of the TNZTS alloy was evaluated using SCP-1, SaOs-2, and THP-1 cell lines and primary human osteoblasts. Compared to Ti-6Al-4V, the elastic modulus of TNZTS alloy was significantly lower, while measures of its in vitro biocompatibility are comparable. O2 plasma treatment of the surface of the alloy significantly increased its hydrophilicity and, hence, its in vitro biocompatibility. TNZTS alloy specimens did not induce the release of cytokines by macrophages, indicating that such scaffolds would not trigger inflammatory responses. The present results suggest that the TNZTS alloy may have potential as an alternative to Ti-6Al-4V. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.|
LOW-MODULUS TI ALLOYS
O2 PLASMA TREATMENT
TITANIUM ALLOY (TIAL6V4)
ENZYME LINKED IMMUNOSORBENT ASSAY
IN VITRO STUDY
LIMIT OF QUANTITATION
PERIPHERAL BLOOD MONONUCLEAR CELL
SAOS-2 CELL LINE
SCANNING ELECTRON MICROSCOPY
THP-1 CELL LINE
TRANSMISSION ELECTRON MICROSCOPY
X RAY DIFFRACTION
PROSTHESES AND ORTHOSES
HYDROPHOBIC AND HYDROPHILIC INTERACTIONS
PROSTHESES AND IMPLANTS
|metadata.dc.description.sponsorship:||Funding: The experimental work was funded by the State Assignment (Russian Federation, Grant No. 0836-2020-0020) and DAAD together with the Ministry of Education and Science of the Russian Federation within the Michael Lomonosov Program (project No. 57447934).|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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