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dc.contributor.authorKhokhlova, A.en
dc.contributor.authorMyachina, T.en
dc.contributor.authorVolzhaninov, D.en
dc.contributor.authorButova, X.en
dc.contributor.authorKochurova, A.en
dc.contributor.authorBerg, V.en
dc.contributor.authorGette, I.en
dc.contributor.authorMoroz, G.en
dc.contributor.authorKlinova, S.en
dc.contributor.authorMinigalieva, I.en
dc.contributor.authorSolovyova, O.en
dc.contributor.authorDanilova, I.en
dc.contributor.authorSokolova, K.en
dc.contributor.authorKopylova, G.en
dc.contributor.authorShchepkin, D.en
dc.date.accessioned2022-05-12T08:24:44Z-
dc.date.available2022-05-12T08:24:44Z-
dc.date.issued2022-
dc.identifier.citationType 1 Diabetes Impairs Cardiomyocyte Contractility in the Left and Right Ventricular Free Walls but Preserves It in the Interventricular Septum / A. Khokhlova, T. Myachina, D. Volzhaninov et al. // International Journal of Molecular Sciences. — 2022. — Vol. 23. — Iss. 3. — 1719.en
dc.identifier.issn1661-6596-
dc.identifier.otherAll Open Access, Gold, Green3
dc.identifier.urihttp://elar.urfu.ru/handle/10995/111877-
dc.description.abstractType 1 diabetes (T1D) leads to ischemic heart disease and diabetic cardiomyopathy. We tested the hypothesis that T1D differently affects the contractile function of the left and right ventricular free walls (LV, RV) and the interventricular septum (IS) using a rat model of alloxan-induced T1D. Single-myocyte mechanics and cytosolic Ca2+ concentration transients were studied on cardiomyocytes (CM) from LV, RV, and IS in the absence and presence of mechanical load. In addition, we analyzed the phosphorylation level of sarcomeric proteins and the characteristics of the actin-myosin interaction. T1D similarly affected the characteristics of actin-myosin interaction in all studied regions, decreasing the sliding velocity of native thin filaments over myosin in an in vitro motility assay and its Ca2+ sensitivity. A decrease in the thin-filament velocity was associated with increased expression of β-myosin heavy-chain isoform. However, changes in the mechanical function of single ventricular CM induced by T1D were different. T1D depressed the contractility of CM from LV and RV; it decreased the auxotonic tension amplitude and the slope of the active tension-length relationship. Nevertheless, the contractile function of CM from IS was principally preserved. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.sponsorshipFunding: This work was supported by the Russian Science Foundation № 18-74-10059. The work was performed using the equipment of the Shared Research Center of Scientific Equipment of Institute of Immunology and Physiology.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen1
dc.publisherMDPI AGen
dc.relationinfo:eu-repo/grantAgreement/RSF//18-74-10059en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceInt. J. Mol. Sci.2
dc.sourceInternational Journal of Molecular Sciencesen
dc.subjectACTIN-MYOSIN INTERACTIONen
dc.subjectCALCIUM TRANSIENTSen
dc.subjectDIABETIC CARDIOMYOPATHYen
dc.subjectINTERVENTRICULAR DIFFERENCESen
dc.subjectSINGLE CARDIOMYOCYTE MECHANICSen
dc.subjectTENSION-LENGTH RELATIONSHIPen
dc.subjectCALCIUMen
dc.subjectANIMALen
dc.subjectCARDIAC MUSCLE CELLen
dc.subjectHEART CONTRACTIONen
dc.subjectHEART VENTRICLE FUNCTIONen
dc.subjectINSULIN DEPENDENT DIABETES MELLITUSen
dc.subjectMALEen
dc.subjectMETABOLISMen
dc.subjectPATHOLOGYen
dc.subjectRATen
dc.subjectWISTAR RATen
dc.subjectANIMALSen
dc.subjectCALCIUMen
dc.subjectDIABETES MELLITUS, TYPE 1en
dc.subjectMYOCARDIAL CONTRACTIONen
dc.subjectMYOCYTES, CARDIACen
dc.subjectRATSen
dc.subjectRATS, WISTARen
dc.subjectVENTRICULAR FUNCTIONen
dc.titleType 1 Diabetes Impairs Cardiomyocyte Contractility in the Left and Right Ventricular Free Walls but Preserves It in the Interventricular Septumen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3390/ijms23031719-
dc.identifier.scopus85124365907-
local.contributor.employeeKhokhlova, A., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation, Ural Federal University, Mira 19, Yekaterinburg, 620002, Russian Federation; Myachina, T., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Volzhaninov, D., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Butova, X., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Kochurova, A., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Berg, V., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Gette, I., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation, Ural Federal University, Mira 19, Yekaterinburg, 620002, Russian Federation; Moroz, G., Ural Federal University, Mira 19, Yekaterinburg, 620002, Russian Federation; Klinova, S., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Popova 30, Yekaterinburg, 620014, Russian Federation; Minigalieva, I., Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Popova 30, Yekaterinburg, 620014, Russian Federation; Solovyova, O., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation, Ural Federal University, Mira 19, Yekaterinburg, 620002, Russian Federation; Danilova, I., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Sokolova, K., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Kopylova, G., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Shchepkin, D., Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federationen
local.issue3-
local.volume23-
dc.identifier.wos000755278800001-
local.contributor.departmentInstitute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, Yekaterinburg, 620049, Russian Federation; Ural Federal University, Mira 19, Yekaterinburg, 620002, Russian Federation; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Popova 30, Yekaterinburg, 620014, Russian Federationen
local.identifier.pure29632037-
local.description.order1719-
local.identifier.eid2-s2.0-85124365907-
local.fund.rsf18-74-10059-
local.identifier.wosWOS:000755278800001-
local.identifier.pmid35163643-
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