Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111856
Title: The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models
Authors: Lieggi, C.
Kalueff, A. V.
Lawrence, C.
Collymore, C.
Issue Date: 2020
Publisher: Oxford University Press
Oxford University Press (OUP)
Citation: The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models / C. Lieggi, A. V. Kalueff, C. Lawrence et al. // ILAR Journal. — 2020. — Vol. 60. — Iss. 2. — P. 270-288.
Abstract: The publication of reproducible, replicable, and translatable data in studies utilizing animal models is a scientific, practical, and ethical necessity. This requires careful planning and execution of experiments and accurate reporting of results. Recognition that numerous developmental, environmental, and test-related factors can affect experimental outcomes is essential for a quality study design. Factors commonly considered when designing studies utilizing aquatic animal species include strain, sex, or age of the animal; water quality; temperature; and acoustic and light conditions. However, in the aquatic environment, it is equally important to consider normal species behavior, group dynamics, stocking density, and environmental complexity, including tank design and structural enrichment. Here, we will outline normal species and social behavior of 2 commonly used aquatic species: zebrafish (Danio rerio) and Xenopus (X. laevis and X. tropicalis). We also provide examples as to how these behaviors and the complexity of the tank environment can influence research results and provide general recommendations to assist with improvement of reproducibility and replicability, particularly as it pertains to behavior and environmental complexity, when utilizing these popular aquatic models. © The Author(s) 2020. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved.
Keywords: BEHAVIOR
ENRICHMENT
HUSBANDRY
NEUROBEHAVIOR
REPLICABILITY
REPRODUCIBILITY
XENOPUS
ZEBRAFISH
ANIMAL EXPERIMENT
ANIMAL MODEL
AQUATIC ENVIRONMENT
AQUATIC SPECIES
ARTICLE
ENVIRONMENTAL FACTOR
FEMALE
GROUP DYNAMICS
MALE
NONHUMAN
REPRODUCIBILITY
STOCKING DENSITY
WATER QUALITY
XENOPUS
ZEBRA FISH
ANIMAL
ANIMAL BEHAVIOR
ANIMAL HOUSING
ANIMAL WELFARE
PHYSIOLOGY
REPRODUCIBILITY
XENOPUS
ZEBRA FISH
ANIMAL WELFARE
ANIMALS
BEHAVIOR, ANIMAL
HOUSING, ANIMAL
MODELS, ANIMAL
REPRODUCIBILITY OF RESULTS
XENOPUS
ZEBRAFISH
URI: http://hdl.handle.net/10995/111856
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85094221407
PURE ID: 20112090
ISSN: 1084-2020
metadata.dc.description.sponsorship: A.V.K. research was supported by the Russian Science Foundation grant 19-15-00053. He is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC). This collaboration was supported, in part, through the NIH/NCI Cancer Center Support Grant P30 CA008748. The authors would like to thank Gregory Paull for sharing his photographs and insight into the natural habitat of zebrafish in Bangladesh.
RSCF project card: 19-15-00053
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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