Please use this identifier to cite or link to this item:
|Title:||The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models|
Kalueff, A. V.
|Publisher:||Oxford University Press|
Oxford University Press (OUP)
|Citation:||The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models / C. Lieggi, A. V. Kalueff, C. Lawrence et al. // ILAR Journal. — 2020. — Vol. 60. — Iss. 2. — P. 270-288.|
|Abstract:||The publication of reproducible, replicable, and translatable data in studies utilizing animal models is a scientific, practical, and ethical necessity. This requires careful planning and execution of experiments and accurate reporting of results. Recognition that numerous developmental, environmental, and test-related factors can affect experimental outcomes is essential for a quality study design. Factors commonly considered when designing studies utilizing aquatic animal species include strain, sex, or age of the animal; water quality; temperature; and acoustic and light conditions. However, in the aquatic environment, it is equally important to consider normal species behavior, group dynamics, stocking density, and environmental complexity, including tank design and structural enrichment. Here, we will outline normal species and social behavior of 2 commonly used aquatic species: zebrafish (Danio rerio) and Xenopus (X. laevis and X. tropicalis). We also provide examples as to how these behaviors and the complexity of the tank environment can influence research results and provide general recommendations to assist with improvement of reproducibility and replicability, particularly as it pertains to behavior and environmental complexity, when utilizing these popular aquatic models. © The Author(s) 2020. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved.|
REPRODUCIBILITY OF RESULTS
|metadata.dc.description.sponsorship:||A.V.K. research was supported by the Russian Science Foundation grant 19-15-00053. He is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC). This collaboration was supported, in part, through the NIH/NCI Cancer Center Support Grant P30 CA008748. The authors would like to thank Gregory Paull for sharing his photographs and insight into the natural habitat of zebrafish in Bangladesh.|
|RSCF project card:||19-15-00053|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.