Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111853
Title: Flatness-Based Control Approach to Drug Infusion for Cardiac Function Regulation
Authors: Rigatos, G.
Zervos, N.
Melkikh, A.
Issue Date: 2017
Publisher: Institution of Engineering and Technology
Institution of Engineering and Technology (IET)
Citation: Rigatos G. Flatness-Based Control Approach to Drug Infusion for Cardiac Function Regulation / G. Rigatos, N. Zervos, A. Melkikh // IET Systems Biology. — 2017. — Vol. 11. — Iss. 1. — P. 8-18.
Abstract: A new control method based on differential flatness theory is developed in this study, aiming at solving the problem of regulation of haemodynamic parameters. Actually control of the cardiac output (volume of blood pumped out by heart per unit of time) and of the arterial blood pressure is achieved through the administered infusion of cardiovascular drugs such as dopamine and sodium nitroprusside. Time delays between the control inputs and the system's outputs are taken into account. Using the principle of dynamic extension, which means that by considering certain control inputs and their derivatives as additional state variables, a state-space description for the heart's function is obtained. It is proven that the dynamic model of the heart is a differentially flat one. This enables its transformation into a linear canonical and decoupled form, for which the design of a stabilising feedback controller becomes possible. The proposed feedback controller is of proven stability and assures fast and accurate tracking of the reference setpoints by the outputs of the heart's dynamic model. Moreover, by using a Kalman filter-based disturbances' estimator, it becomes possible to estimate in real-time and compensate for the model uncertainty and external perturbation inputs that affect the heart's model. © The Institution of Engineering and Technology.
Keywords: BLOOD PRESSURE
CONTROLLERS
DRUG INFUSION
DYNAMIC MODELS
FEEDBACK CONTROL
HEART
LINEAR TRANSFORMATIONS
MATHEMATICAL TRANSFORMATIONS
TIME DELAY
UNCERTAINTY ANALYSIS
ARTERIAL BLOOD PRESSURE
DIFFERENTIAL FLATNESS THEORIES
EXTERNAL PERTURBATIONS
FEEDBACK CONTROLLER
FLATNESS-BASED CONTROL
MODEL UNCERTAINTIES
SODIUM NITROPRUSSIDE
STATE-SPACE DESCRIPTION
FEEDBACK
CARDIOVASCULAR AGENT
ANIMAL
ARTERIAL PRESSURE
BIOLOGICAL MODEL
COMPUTER ASSISTED DRUG THERAPY
COMPUTER SIMULATION
DOSE RESPONSE
DRUG EFFECTS
HEART OUTPUT
HUMAN
INTRAARTERIAL DRUG ADMINISTRATION
PHYSIOLOGY
PROCEDURES
TREATMENT OUTCOME
CARDIAC OUTPUT
CARDIOVASCULAR AGENTS
COMPUTER SIMULATION
DOSE-RESPONSE RELATIONSHIP, DRUG
DRUG THERAPY, COMPUTER-ASSISTED
INFUSIONS, INTRA-ARTERIAL
MODELS, CARDIOVASCULAR
URI: http://hdl.handle.net/10995/111853
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85015679692
PURE ID: 1688993
ISSN: 1751-8849
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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