Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111829
Title: Terbium Medical Radioisotope Production: Laser Resonance Ionization Scheme Development
Authors: Gadelshin, V. M.
Formento, Cavaier, R.
Haddad, F.
Heinke, R.
Stora, T.
Studer, D.
Weber, F.
Wendt, K.
Issue Date: 2021
Publisher: Frontiers Media S.A.
Frontiers Media SA
Citation: Gadelshin V. M. Terbium Medical Radioisotope Production: Laser Resonance Ionization Scheme Development / V. M. Gadelshin, Cavaier R. Formento, F. Haddad // Frontiers in Medicine. — 2021. — Vol. 8. — 727557.
Abstract: Terbium (Tb) is a promising element for the theranostic approach in nuclear medicine. The new CERN-MEDICIS facility aims for production of its medical radioisotopes to support related R&D projects in biomedicine. The use of laser resonance ionization is essential to provide radioisotopic yields of highest quantity and quality, specifically regarding purity. This paper presents the results of preparation and characterization of a suitable two-step laser resonance ionization process for Tb. By resonance excitation via an auto-ionizing level, the high ionization efficiency of 53% was achieved. To simulate realistic production conditions for Tb radioisotopes, the influence of a surplus of Gd atoms, which is a typical target material for Tb generation, was considered, showing the necessity of radiochemical purification procedures before mass separation. Nevertheless, a 10-fold enhancement of the Tb ion beam using laser resonance ionization was observed even with Gd:Tb atomic ratio of 100:1. © Copyright © 2021 Gadelshin, Formento Cavaier, Haddad, Heinke, Stora, Studer, Weber and Wendt.
Keywords: CERN-MEDICIS
GADOLINIUM
ISOTOPE SEPARATION
LASER RESONANCE IONIZATION
RISIKO MASS SEPARATOR
TERBIUM
THERANOSTICS
TI:SAPPHIRE LASER
TANTALUM
TERBIUM
ARTICLE
ATOMIC SPECTROMETRY
COMPARATIVE STUDY
CONTROLLED STUDY
ION CURRENT
IONIZATION
LASER RESONANCE IONIZATION
RADIOCHEMISTRY
SURFACE PROPERTY
URI: http://hdl.handle.net/10995/111829
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85117962857
PURE ID: 23972657
ISSN: 2296-858X
metadata.dc.description.sponsorship: This research project has been supported by a Marie Skłodowska-Curie Innovative Training Network Fellowship of the European Commission’s Horizon 2020 Programme under contract number 642889 MEDICIS-PROMED; by the German Federal Ministry of Education and Research under the consecutive projects 05P12UMCIA and 05P15UMCIA. It has been also partially supported by Equipex ARRONAX-Plus (ANR-11-EQPX-0004), Labex IRON (ANR-11-LABX-18-01), ISITE NExT (ANR-16-IDEX-0007).
CORDIS project card: H2020: 642889
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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