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|Title:||Echogenic Advantages of Ferrogels Filled with Magnetic Sub-microparticles|
|Authors:||Dinislamova, O. A.|
Bugayova, A. V.
Shklyar, T. F.
Safronov, A. P.
Blyakhman, F. A.
|Citation:||Echogenic Advantages of Ferrogels Filled with Magnetic Sub-microparticles / O. A. Dinislamova, A. V. Bugayova, T. F. Shklyar et al. // Bioengineering. — 2021. — Vol. 8. — Iss. 10. — 140.|
|Abstract:||Ultrasonic imaging of ferrogels (FGs) filled with magnetic nanoparticles does not reflect the inner structure of FGs due to the small size of particles. To determine whether larger particle size would improve the acoustic properties of FGs, biocompatible hydrogels filled with 100–400 nm iron oxide magnetic sub-microparticles with weight fraction up to 23.3% were synthesized and studied. Polymeric networks of synthesized FGs were comprised of chemically cross-linked polyacrylamide with interpenetrating physical network of natural polysaccharide—Guar or Xanthan. Cylindrical samples approximately 10 mm in height and 13 mm in diameter were immersed in a water bath and examined using medical ultrasound (8.5 MHz). The acoustic properties of FGs were characterized by the intensity of reflected echo signal. It was found that the echogenicity of sub-microparticles provides visualization not only of the outer geometry of the gel sample but of its inner structure as well. In particular, the echogenicity of FGs interior depended on the concentration of magnetic particles in the FGs network. The ultrasound monitoring of the shape, dimensions, and inner structure of FGs in the applied external magnetic field is demonstrated. It is especially valuable for the application of FGs in tissue engineering and regenerative medicine. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.|
|metadata.dc.description.sponsorship:||The study was supported by the program of the Ministry of Health of the Russian Federation (project 121032300335-1). A.P. Safronov appreciates the Russian Science Foundation (grant 20-12-00031) financial support in the characterization of iron oxide particles, and in the synthesis and characterization of ferrogels.|
|RSCF project card:||20-12-00031|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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