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Title: Modeling of Cerium Oxide Nanoparticles Pharmacokinetics
Authors: Kasyanova, V. V.
Bazhukova, I. N.
Issue Date: 2020
Publisher: American Institute of Physics Inc.
AIP Publishing
Citation: Kasyanova V. V. Modeling of Cerium Oxide Nanoparticles Pharmacokinetics / V. V. Kasyanova, I. N. Bazhukova // AIP Conference Proceedings. — 2020. — Vol. 2313. — 080015.
Abstract: Cerium oxide nanoparticles have recently attracted great attention as one of the promising nanomaterials for use in the pharmaceutical industry. However, to assess the potential toxicity of these nanoparticles, information about their biodistribution in the body is necessary. A physiologically based pharmacokinetic (PBPK) modeling is a convenient tool for providing such data. So, this study is devoted to modeling the pharmacokinetics of intravenously injected CeO2 nanoparticles in the body. The designed PBPK model adequately described time courses of CeO2 nanoparticles in various tissues of rats. Simulation results allow to analyze absorption, distribution, metabolism, and excretion of nanoparticles in the body, and provide important information to evaluate their toxicity to biological organisms. © 2020 American Institute of Physics Inc.. All rights reserved.
Access: info:eu-repo/semantics/openAccess
Conference name: 7th International Young Researchers'' Conference on Physics, Technology, Innovations, PTI 2020
Conference date: 18 May 2020 through 22 May 2020
SCOPUS ID: 85097999558
PURE ID: 20400161
ISSN: 0094-243X
ISBN: 9780735440531
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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