Modeling of Cerium Oxide Nanoparticles Pharmacokinetics

Abstract

Cerium oxide nanoparticles have recently attracted great attention as one of the promising nanomaterials for use in the pharmaceutical industry. However, to assess the potential toxicity of these nanoparticles, information about their biodistribution in the body is necessary. A physiologically based pharmacokinetic (PBPK) modeling is a convenient tool for providing such data. So, this study is devoted to modeling the pharmacokinetics of intravenously injected CeO2 nanoparticles in the body. The designed PBPK model adequately described time courses of CeO2 nanoparticles in various tissues of rats. Simulation results allow to analyze absorption, distribution, metabolism, and excretion of nanoparticles in the body, and provide important information to evaluate their toxicity to biological organisms. © 2020 American Institute of Physics Inc.. All rights reserved.