Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111569
Title: Evaluation of the Long-term Effectiveness of Cardiac Resynchronization Therapy
Authors: Chumarnaya, T. V.
Lyubimtseva, T. A.
Solodushkin, S. I.
Lebedeva, V. K.
Lebedev, D. S.
Solovieva, O. E.
Issue Date: 2021
Publisher: Silicea-Poligraf
Silicea - Poligraf, LLC
Citation: Evaluation of the Long-term Effectiveness of Cardiac Resynchronization Therapy / T. V. Chumarnaya, T. A. Lyubimtseva, S. I. Solodushkin et al. // Russian Journal of Cardiology. — 2021. — Vol. 26. — Iss. 7. — P. 48-60. — 4531.
Abstract: Aim. To determine quantitative criteria for assessing the therapeutic benefits and the most informative time frames after cardiac resynchronization therapy (CRT) to assess its long-term effectiveness (1, 2, 3 years of follow-up) based on retrospective analysis. To assess the CRT effectiveness, parameters of left ventricular (LV) reverse remodeling and signs characterizing the clinical CRT response were considered. Material and methods. This single-center, retrospective, non-randomized study included data from 278 patients with implanted CRT devices. Quantitative criteria for assessing CRT effectiveness were determined using a two-step cluster analysis of patients 1, 2, and 3 years after CRT by LV reverse remodeling parameters. Results. In the dataset with satisfactory division accuracy, after the first year, two clusters were identified, which are conventionally named as “non-responders” and “responders”. Two and three years after therapy, patients were classified into three clusters: “non-responders”, “responders” and “super-responders”. For the obtained clusters, we found cutoff values for LV reverse remodeling parameters, which can be used as criteria for response to therapy. The study identified the most informative time frames for assessing the postoperative CRT effectiveness 1, 2, 3 years after the surgery. At the same time, the clinical response to therapy is manifested earlier in comparison with the reverse LV remodeling. Despite the high divisibility of patients into responders and non-responders, predictive models of CRT effectiveness created using the available data from standard diagnostic protocols for heart failure patients have insufficient accuracy to be used for making decisions on therapy appropriateness. This circumstance indicates the need to receive additional data to improve the forecasting quality. Conclusion. The study revealed a period for assessing the clinical response and changes in LV reverse remodeling after CRT surgery, which is important for the optimal choice of postoperative therapy. It has been shown that in most cases, one year after surgery is sufficient to assess the clinical response, and the process of LV reverse remodeling can last up to two years on average. When assessing the CRT effectiveness by reverse remodeling, along with a change in LV end-systolic volume (ESV), it is necessary to take into account LV end-diastolic volume (EDV) changes. The change in LV ejection fraction showed a significantly lower value among the analyzed parameters in assessing the CRT effectiveness. Based on the cluster classification of patients, a dividing rule was established for responders and non-responders in the first and second years after surgery with an accuracy of 97%: a decrease in LV ESV and EDV by 9% or more compared to preoperative values. © 2021, Silicea-Poligraf. All rights reserved.
Keywords: CARDIAC RESYNCHRONIZATION THERAPY
CARDIAC RESYNCHRONIZATION THERAPY EFFECTIVENESS
FORECASTING MODELS
LONG-TERM POSTOPERATIVE PERIOD
ADULT
ARTICLE
CARDIAC RESYNCHRONIZATION THERAPY
CLUSTER ANALYSIS
CONTROLLED STUDY
FOLLOW UP
FORECASTING
HEART FAILURE
HEART LEFT VENTRICLE
HEART LEFT VENTRICLE EJECTION FRACTION
HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME
HEART VENTRICLE REMODELING
HUMAN
MAJOR CLINICAL STUDY
POSTOPERATIVE PERIOD
RETROSPECTIVE STUDY
THERAPY EFFECT
TREATMENT RESPONSE
URI: http://hdl.handle.net/10995/111569
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85117571207
PURE ID: 23015014
ISSN: 1560-4071
metadata.dc.description.sponsorship: Relationships and Activities. This work was supported by a Russian Science Foundation grant № 19-14-00134.
RSCF project card: 19-14-00134
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

Files in This Item:
File Description SizeFormat 
2-s2.0-85117571207.pdf813,89 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.