Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111275
Title: Remodeling of the Heart of the Premature Child
Other Titles: Ремоделирование сердца недоношенных детей
Authors: Tsyvian, P. B.
Kovtun, O. P.
Markova, T. V.
Chumarnaya, T. V.
Issue Date: 2020
Publisher: Meditsina Publishers
Paediatrician Publishers LLC
Citation: Remodeling of the Heart of the Premature Child [Ремоделирование сердца недоношенных детей] / P. B. Tsyvian, O. P. Kovtun, T. V. Markova et al. // Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. — 2020. — Vol. 75. — Iss. 6. — P. 631-637.
Abstract: Epidemiological studies consistently have suggested an association between low birth weight and increased rate of cardiovascular morbidity and mortality in adult life. Preterm birth, as one of the leading causes of the low birth weight, is associated with cardiovascular remodeling which consists of changes in heart chambers geometry and contraction-relaxation mode, ventricular hypertrophy, arterial wall structure and density changes. Several types of preterm birth are discussed: prematurity, associated with placental insufficiency and fetal growth restriction, preterm leaking of amniotic fluid, and twin pregnancy. DNA methylation process under the influence of epigenetic factors of the intrauterine and early postnatal development is suggested as a one of the main mechanism of cardiovascular remodeling in preterm infants. The other mechanisms of cardiovascular remodeling are discussed in terms of the modern intrauterine programming concept. The early diagnostics and prevention of cardiovascular diseases in preterm born children are discussed. The treatment during prenatal and early postnatal periods as well as prevention of the remodeling causes could diminish and even reverse the development of the negative cardiovascular events and diseases in later life according to the so called concept of “one thousand days opportunities window”. © 2020 Izdatel'stvo Meditsina. All rights reserved.
Keywords: CARDIOVASCULAR DISEASES
DIAGNOSTICS
FETAL PROGRAMMING
PRETERM BIRTH
PREVENTION
AMNION FLUID
CARDIOVASCULAR DISEASE
FETUS GROWTH
HEART VENTRICLE HYPERTROPHY
HEART VENTRICLE REMODELING
HUMAN
LOW BIRTH WEIGHT
PERINATAL PERIOD
PLACENTA INSUFFICIENCY
PREMATURE LABOR
PREMATURITY
REVIEW
TWIN PREGNANCY
URI: http://hdl.handle.net/10995/111275
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85108224279
PURE ID: 20908025
ISSN: 0869-6047
metadata.dc.description.sponsorship: Работа выполнена при финансовой поддержке ФГБОУ ВО УГМУ Минздрава России в рамках госзадания ИИФ УрО РАН (тема № АААА-А18-118020590031-8) и поддержана постановлением Правительства РФ от 16.03.2013 № 211 (соглашение 02.A03.21.0006).
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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