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Title: Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels
Authors: Okenov, A. O.
Iaparov, B. I.
Moskvin, A. S.
Issue Date: 2019
Publisher: Pleiades Publishing
Pleiades Publishing Ltd
Citation: Okenov A. O. Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels / A. O. Okenov, B. I. Iaparov, A. S. Moskvin. — DOI 10.3390/su132413975 // JETP Letters. — 2019. — Vol. 110. — Iss. 3. — P. 231-236.
Abstract: Six thermo-activated transient receptor potential (TRP) channels are the molecular basis of the thermosensation for mammals. However, the molecular source of their gating remains unknown. In the Letter, we suggest a physically based model for the TRP channels and show that the temperature dependence of the “internal friction” can be a key factor governing the ion channels gating. Results of the computer modeling allowed us to successfully reproduce the experimental data for the open probability Popen of the TRPV1 and TRPM8 channels at different temperatures and voltages. © 2019, Pleiades Publishing, Inc.
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85073647340
PURE ID: 11119721
ISSN: 0021-3640
DOI: 10.3390/su132413975
metadata.dc.description.sponsorship: This work was supported by the Government of the Russian Federation (agreement no. 02.A03.21.0006, Act 211) and by the Ministry of Education and Science of the Russian Federation (project nos. 2277 and 5719).
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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