Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111168
Title: Multiparametric Analysis of Geometric Features of Fibrotic Textures Leading to Cardiac Arrhythmias
Authors: Nezlobinsky, T.
Okenov, A.
Panfilov, A. V.
Issue Date: 2021
Publisher: Nature Research
Springer Science and Business Media LLC
Citation: Nezlobinsky T. Multiparametric Analysis of Geometric Features of Fibrotic Textures Leading to Cardiac Arrhythmias / T. Nezlobinsky, A. Okenov, A. V. Panfilov // Scientific Reports. — 2021. — Vol. 11. — Iss. 1. — 21111.
Abstract: One of the important questions in cardiac electrophysiology is to characterise the arrhythmogenic substrate; for example, from the texture of the cardiac fibrosis, which is considered one of the major arrhythmogenic conditions. In this paper, we perform an extensive in silico study of the relationships between various local geometric characteristics of fibrosis on the onset of cardiac arrhythmias. In order to define which texture characteristics have better predictive value, we induce arrhythmias by external stimulation, selecting 4363 textures in which arrhythmia can be induced and also selecting 4363 non-arrhythmogenic textures. For each texture, we determine such characteristics as cluster area, solidity, mean distance, local density and zig-zag propagation path, and compare them in arrhythmogenic and non-arrhythmogenic cases. Our study shows that geometrical characteristics, such as cluster area or solidity, turn out to be the most important for prediction of the arrhythmogenic textures. Overall, we were able to achieve an accuracy of 67% for the arrhythmogenic texture-classification problem. However, the accuracy of predictions depends on the size of the region chosen for the analysis. The optimal size for the local areas of the tissue was of the order of 0.28 of the wavelength of the arrhythmia. We discuss further developments and possible applications of this method for characterising the substrate of arrhythmias in fibrotic textures. © 2021, The Author(s).
Keywords: BIOLOGICAL MODEL
FIBROSIS
HEART ARRHYTHMIA
HUMAN
PATHOLOGY
PATHOPHYSIOLOGY
ARRHYTHMIAS, CARDIAC
FIBROSIS
HUMANS
MODELS, CARDIOVASCULAR
URI: http://hdl.handle.net/10995/111168
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85118274188
PURE ID: 28889095
ISSN: 2045-2322
metadata.dc.description.sponsorship: Research was funded by the Russian Foundation for Basic Research (№ 18-29-13008) and BOF of Ghent University.
RSCF project card: 18-29-13008
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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