Green synthesis of 2-amino-3-cyano-4 H-chromen-4-ylphosphonates

Abstract

A facile and highly efficient and green synthetic protocol is developed for the bioactive 2-amino-3-cyano-4H-chromen-4-ylphosphonates by the one-pot reaction of various salicylaldehydes, malononitrile, and diethyl phosphite using sulfamic acid as an efficient, reusable and heterogeneous solid acid catalyst. All the synthesized compounds were characterized by their 1H-NMR, 13C-NMR, 31P-NMR, and Mass spectral studies. © 2020 Author(s).