Calcium bromide catalysed synthesis and anticoagulant activity of bis(α-aminophosphonates)

Abstract

A simple and efficient microwave irradiated synthesis of bis(α-aminophosphonates) has been developed by the reaction of 1,2-diphenylethane-1,2-diamine, aromatic aldehydes, and dimethyl phosphite in the presence of calcium bromide as catalyst under neat conditions at room temperature. All the title compounds were screened for their anticoagulant activity using blockasol as standard. The compounds containing thio group exhibited promising anticoagulant activity when compared to blockasol. © 2020 Author(s).