Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/103298
Title: Synthesis and cytotoxic activity of various alkyl 2-{di[(diethoxy phosphoryl)methyl]amino}ester derivatives
Authors: Reddy, C. B.
Reddy, N. B.
Raju, C. N.
Issue Date: 2020
Publisher: American Institute of Physics Inc.
Citation: Reddy C. B. Synthesis and cytotoxic activity of various alkyl 2-{di[(diethoxy phosphoryl)methyl]amino}ester derivatives / C. B. Reddy, N. B. Reddy, C. N. Raju. — DOI 10.1063/5.0018370 // AIP Conference Proceedings. — 2020. — Vol. 2280. — 0018370.
Abstract: We have been synthesized simple, efficient various alkyl 2-{di[(diethoxy phosphoryl) methyl]amino}ester derivatives by reacting amino acid esters 1(a-j), paraformaldehyde and two molar equivalents of diethyl hydrogenphosphonate (2) in tetrahydrofuran at 55-65 °C for 10 hrs. All the compounds 3(a-j) were assessed for cytotoxicity against some important types of human chronic myeloid leukemia cells (K-562) and human colon carcinoma cells (Colo-205) along with noncancerous human embryonic kidney cells (HEK-293). © 2020 Author(s).
URI: http://hdl.handle.net/10995/103298
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85096446798
PURE ID: 20128877
63e15370-b44b-40af-b3ed-370654691f14
ISSN: 0094243X
ISBN: 9780735440104
DOI: 10.1063/5.0018370
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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