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|Title:||Overdrive pacing of spiral waves in a model of human ventricular tissue|
|Authors:||Pravdin, S. F.|
Epanchintsev, T. I.
Panfilov, A. V.
|Citation:||Pravdin S. F. Overdrive pacing of spiral waves in a model of human ventricular tissue / S. F. Pravdin, T. I. Epanchintsev, A. V. Panfilov. — DOI 10.1038/s41598-020-77314-5 // Scientific Reports. — 2020. — Vol. 10. — Iss. 1. — 20632.|
|Abstract:||High-voltage electrical defibrillation remains the only reliable method of quickly controlling life-threatening cardiac arrhythmias. This paper is devoted to studying an alternative approach, low-voltage cardioversion (LVC), which is based on ideas from non-linear dynamics and aims to remove sources of cardiac arrhythmias by applying high-frequency stimulation to cardiac tissue. We perform a detailed in-silico study of the elimination of arrhythmias caused by rotating spiral waves in a TP06 model of human cardiac tissue. We consider three parameter sets with slopes of the APD restitution curve of 0.7, 1.1 and 1.4, and we study LVC at the baseline and under the blocking of INa and ICaL and under the application of the drugs verapamil and amiodarone. We show that pacing can remove spiral waves; however, its efficiency can be substantially reduced by dynamic instabilities. We classify these instabilities and show that the blocking of INa and the application of amiodarone increase the efficiency of the method, while the blocking of ICaL and the application of verapamil decrease the efficiency. We discuss the mechanisms and the possible clinical applications resulting from our study. © 2020, The Author(s).|
HEART MUSCLE CONDUCTION SYSTEM
HEART VENTRICLE FIBRILLATION
HEART CONDUCTION SYSTEM
|metadata.dc.description.sponsorship:||Supported by Russian Science Foundation Project No. 17-71-20024.|
|RSCF project card:||17-71-20024|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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