Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/103119
Title: Green Synthesis, Antioxidant, and Plant Growth Regulatory Activities of Novel α-Furfuryl-2-alkylaminophosphonates
Authors: Nadiveedhi, M. R.
Nuthalapati, P.
Gundluru, M.
Yanamula, M. R.
Kallimakula, S. V.
Pasupuleti, V. R.
Avula, V. K. R.
Vallela, S.
Zyryanov, G. V.
Balam, S. K.
Cirandur, S. R.
Зырянов, Г. В.
Issue Date: 2021
Publisher: American Chemical Society
Citation: Green Synthesis, Antioxidant, and Plant Growth Regulatory Activities of Novel α-Furfuryl-2-alkylaminophosphonates / M. R. Nadiveedhi, P. Nuthalapati, M. Gundluru, et al. — DOI 10.1021/acsomega.0c05302 // ACS Omega. — 2021. — Vol. 6. — Iss. 4. — P. 2934-2948.
Abstract: A series of novel α-furfuryl-2-alkylaminophosphonates have been efficiently synthesized from the one-pot three-component classical Kabachnik-Fields reaction in a green chemical approach by addition of an in situ generated dialkylphosphite to Schiff's base of aldehydes and amines by using environmental and eco-friendly silica gel supported iodine as a catalyst by microwave irradiation. The advantage of this protocol is simplicity in experimental procedures and products were resulted in high isolated yields. The synthesized α-furfuryl-2-alkylaminophosphonates were screened to in vitro antioxidant and plant growth regulatory activities and some are found to be potent with antioxidant and plant growth regulatory activities. These in vitro studies have been further supported by ADMET (absorption, distribution, metabolism, excretion, and toxicity), quantitative structure-activity relationship, molecular docking, and bioactivity studies and identified that they were potentially bound to the GLN340 amino acid residue in chain C of 1DNU protein and TYR597 amino acid residue in chain A of 4M7E protein, causing potential exhibition of antioxidant and plant growth regulatory activities. Eventually, title compounds are identified as good blood-brain barrier (BBB)-penetrable compounds and are considered as proficient central nervous system active and neuroprotective antioxidant agents as the neuroprotective property is determined with BBB penetration thresholds. © 2021 The Authors. Published by American Chemical Society.
URI: http://hdl.handle.net/10995/103119
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85100196164
PURE ID: 21027310
dcfb33c0-fca2-48e4-b651-1beeb91d534d
ISSN: 24701343
DOI: 10.1021/acsomega.0c05302
metadata.dc.description.sponsorship: The author M.R.N. expresses thanks to the Department of Science and Technology, New Delhi, India, for the financial support under DST-INSPIRE Fellowship program no. DST/INSPIRE Fellowship/IF150757, dated: 14/01/16. The author M.G. expresses thanks to DST-PURSE 2 Phase Programme facilitated at Sri Venkateswara University, Tirupati, India, by Department of Science and Technology, New Delhi, India [17118-UGC-III(3)/DST-PURSE 2nd Phase/2017, Dt: 23-08-2018], for funding. The authors V.K.R.A. and G.V.Z. are thankful to Ural Federal University for support and acknowledge the financial support of the Russian Science Foundation, Moscow, Russian Federation (RSF grant no.: 18-13-00365). The authors also acknowledge C. Devendranath Reddy (Retd.), Sri Venkateswara University, Tirupati, India, for the guidance. nd
RSCF project card: 18-13-00365
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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