Application of the fibrous autograft in posttraumatic bone regeneration of the lower jaw

Abstract

The search for new types of bone substitutes is one of the topical problems of biology and medicine. The paper considered the role of fibrous autograft in reparative bone regeneration in the rat's lower jaw model. Thirty Wistar rats were taken in the experiment: 15 in the experimental and 15 in the control group. Fibrous autograft was formed on the cellophane basis under the skin on the back of rats. Injury in the lower jaw with a diameter of 2 mm was formed and a fibrous graft was placed in injuries in the experimental group. Five animals from each groups were sacrificed at the first, third and fifth weeks of the experiment. The object of the further research was the samples of the lower jaws stained according to Van Gieson. Histological examination of the bone defect of the experimental group after 1 week showed absence of bone fragments and formation of fibrous callosity in the trauma zone. Further study of regenerate at the 3rd and the 5th weeks showed accelerated bone wound healing in the experimental group (compared to the control group). Thus, the autograft stimulates the process of bone tissue restoration in the area of the defect of the lower jaw model. © 2021 Acta Biomedica Scientifica. All rights reserved.