Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/103045
Title: Alcohol dose in septal ablation for hypertrophic obstructive cardiomyopathy
Authors: Veselka, J.
Faber, L.
Liebregts, M.
Cooper, R.
Januska, J.
Kashtanov, M.
Dabrowski, M.
Hansen, P. R.
Seggewiss, H.
Bonaventura, J.
Polakova, E.
Hansvenclova, E.
Bundgaard, H.
ten, Berg, J.
Stables, R. H.
Jarkovsky, J.
Jensen, M. K.
Issue Date: 2021
Publisher: Elsevier Ireland Ltd
Citation: Alcohol dose in septal ablation for hypertrophic obstructive cardiomyopathy / J. Veselka, L. Faber, M. Liebregts, et al. — DOI 10.1016/j.ijcard.2021.02.056 // International Journal of Cardiology. — 2021. — Vol. 333. — P. 127-132.
Abstract: Background: The aim of this study was to evaluate short- and long-term outcomes related to dose of alcohol administered during alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM). Current guidelines recommend using 1–3 mL of alcohol administered in the target septal perforator artery, but this recommendation is based more on practical experience of interventionalists rather than on systematic evidence. Methods: We included 1448 patients and used propensity score to match patients who received a low-dose (1.0–1.9 mL) versus a high-dose (2.0–3.8 mL) of alcohol during ASA. Results: The matched cohort analysis comprised 770 patients (n = 385 in both groups). There was a similar occurrence of 30-day post-procedural adverse events (13% vs. 12%; p = 0.59), and similar all-cause mortality rates (0.8% vs. 0.5%; p = 1) in the low-dose group and the high-dose group, respectively. In the long-term follow-up (5.4 ± 4.5 years), a total of 110 (14%) patients died representing 2.58 deaths and 2.64 deaths per 100 patient-years in the low dose and the high dose group (logrank, p = 0.92), respectively. There were no significant differences in the long-term dyspnea and left ventricular outflow gradient between the two groups. Patients treated with a low-dose of alcohol underwent more subsequent septal reduction procedures (logrank, p = 0.04). Conclusions: Matched HOCM patients undergoing ASA with a low-dose (1.0–1.9 mL) or a high-dose (2.0–3.8 mL) of alcohol had similar short- and long-term outcomes. A higher rate of repeated septal reduction procedures was observed in the group treated with a low-dose of alcohol. © 2021 The Authors
Keywords: ALCOHOL DOSE
ALCOHOL SEPTAL ABLATION
HYPERTROPHIC CARDIOMYOPATHY
ALCOHOL
ALCOHOL
ADULT
ALCOHOL SEPTAL ABLATION
ALL CAUSE MORTALITY
ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
DRUG DOSE COMPARISON
DRUG MEGADOSE
DYSPNEA
FEMALE
FOLLOW UP
HEART LEFT VENTRICLE OUTFLOW TRACT
HEART TAMPONADE
HEART VENTRICLE FIBRILLATION
HEART VENTRICLE TACHYCARDIA
HUMAN
HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY
LOW DRUG DOSE
MAJOR CLINICAL STUDY
MALE
MORTALITY RATE
PRIORITY JOURNAL
TREATMENT OUTCOME
ABLATION THERAPY
CATHETER ABLATION
DIAGNOSTIC IMAGING
HEART SEPTUM
HYPERTROPHIC CARDIOMYOPATHY
RETROSPECTIVE STUDY
ABLATION TECHNIQUES
CARDIOMYOPATHY, HYPERTROPHIC
CATHETER ABLATION
ETHANOL
HEART SEPTUM
HUMANS
RETROSPECTIVE STUDIES
TREATMENT OUTCOME
URI: http://hdl.handle.net/10995/103045
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85102641313
PURE ID: 21864339
0dabfcd7-1ab8-411a-9616-d5d48e697fd2
ISSN: 1675273
DOI: 10.1016/j.ijcard.2021.02.056
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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