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|Title:||Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use|
|Authors:||Ostroushko, A. A.|
Grzhegorzhevskii, K. V.
Medvedeva, S. Y.
Gette, I. F.
Tonkushina, M. O.
Gagarin, I. D.
Danilova, I. G.
|Citation:||Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use / A. A. Ostroushko, K. V. Grzhegorzhevskii, S. Y. Medvedeva, et al. — DOI 10.17586/2220-8054-2021-12-1-81-112 // Nanosystems: Physics, Chemistry, Mathematics. — 2021. — Vol. 12. — Iss. 1. — P. 81-112.|
|Abstract:||The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered. © 2021, ITMO University. All rights reserved.|
|Keywords:||IMPACT ON LIVING SYSTEMS|
KEPLERATE-TYPE NANOCLUSTER POLYOXOMOLYBDATES
MEANS OF TARGETED DELIVERY
PHYSICOCHEMICAL AND BIOCHEMICAL PROPERTIES
|metadata.dc.description.sponsorship:||The paper was prepared in the framework of implementation of the State Assignment from the Ministry of Education and Science of the Russian Federation (Projects Nos. AAAA-A20-120061990010-7 (FEUZ-2020-0052) and AAAA-A18-118020590107-0), as well as of the Program for Increasing Competitiveness of UrFU (financially supported according to the Decree No. 211 of the Government of the Russian Federation, Contract No. 02.A03.21.0006). The research aimed at creating the long-time drug release systems with feedback was carried out within the framework of the project of the Russian Science Foundation No. 19-73-00177.|
|RSCF project card:||19-73-00177|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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