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Title: Cardioinotropic effects in subchronic intoxication of rats with lead and/or cadmium oxide nanoparticles
Authors: Klinova, S. V.
Katsnelson, B. A.
Minigalieva, I. A.
Gerzen, O. P.
Balakin, A. A.
Lisin, R. V.
Butova, K. A.
Nabiev, S. R.
Lookin, O. N.
Katsnelson, L. B.
Privalova, L. I.
Kuznetsov, D. A.
Shur, V. Ya.
Shishkina, E. V.
Makeev, O. H.
Valamina, I. E.
Panov, V. G.
Sutunkova, M. P.
Nikitina, L. V.
Protsenko, Y. L.
Шур, В. Я.
Issue Date: 2021
Publisher: MDPI AG
Citation: Cardioinotropic effects in subchronic intoxication of rats with lead and/or cadmium oxide nanoparticles / S. V. Klinova, B. A. Katsnelson, I. A. Minigalieva, et al. — DOI 10.3390/ijms22073466 // International Journal of Molecular Sciences. — 2021. — Vol. 22. — Iss. 7. — 3466.
Abstract: Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle trabeculae and papillary muscles in isometric and afterload contractions. Isolated and combined intoxication with these NPs was observed to reduce the mechanical work produced by both types of myocardial preparation. Using the in vitro motility assay, we showed that the sliding velocity of regulated thin filaments drops under both isolated and combined intoxication with CdO– NP and PbO–NP. These results correlate with a shift in the expression of myosin heavy chain (MHC) isoforms towards slowly cycling β–MHC. The type of CdO–NP + PbO–NP combined cardiotoxicity depends on the effect of the toxic impact, the extent of this effect, the ratio of toxicant doses, and the degree of stretching of cardiomyocytes and muscle type studied. Some indices of combined Pb–NP and CdO–NP cardiotoxicity and general toxicity (genotoxicity included) became fully or partly normalized if intoxication developed against background administration of a bioprotective complex. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85103005327
PURE ID: 21172975
ISSN: 16616596
DOI: 10.3390/ijms22073466
metadata.dc.description.sponsorship: The work was carried out partly within the framework of the IIF UrB RAS themes No AAA?A18?118020590031?8 and AAAA?A18?118020590135?3. This work was performed using the equipment of the Shared Research Center of Scientific Equipment SRC IIP UrB RAS.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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