Combination of NH2OHHCl and NaIO4: A new and mild reagent for the synthesis of vicinal diiodo carbonyl compounds

Abstract

The synthesis of vicinal diiodo carbonyl compounds from α,β-unsaturated carbonyl compounds has been carried out for the first time using the combination of NH2OHHCl and NaIO4 under mild reaction conditions at room temperature. The present methodology is also applicable for the synthesis of vicinal diiodo derivatives of nitrostyrene. The remarkable advantages of the present protocol are room temperature reaction, easy operation, good yields, fast reaction, transition metal-free and neutral reaction conditions. The present methodology is applicable to gram scale synthesis. © 2016 Arkat. All rights reserved.