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|Title:||Magnetic properties of iron oxide nanoparticles do not essentially contribute to ferrogel biocompatibility|
|Authors:||Blyakhman, F. A.|
Safronov, A. P.
Makarova, E. B.
Fadeyev, F. A.
Shklyar, T. F.
Shabadrov, P. A.
Armas, S. F.
Kurlyandskaya, G. V.
|Citation:||Magnetic properties of iron oxide nanoparticles do not essentially contribute to ferrogel biocompatibility / F. A. Blyakhman, A. P. Safronov, E. B. Makarova, et al. — DOI 10.3390/nano11041041 // Nanomaterials. — 2021. — Vol. 11. — Iss. 4. — 1041.|
|Abstract:||Two series of composite polyacrylamide (PAAm) gels with embedded superparamagnetic Fe2O3 or diamagnetic Al2O3 nanoparticles were synthesized, aiming to study the direct contribution of the magnetic interactions to the ferrogel biocompatibility. The proliferative activity was estimated for the case of human dermal fibroblast culture grown onto the surfaces of these types of substrates. Spherical non-agglomerated nanoparticles (NPs) of 20–40 nm in diameter were prepared by laser target evaporation (LTE) electrophysical technique. The concentration of the NPs in gel was fixed at 0.0, 0.3, 0.6, or 1.2 wt.%. Mechanical, electrical, and magnetic properties of composite gels were characterized by the dependence of Young’s modulus, electrical potential, magnetization measurements on the content of embedded NPs. The fibroblast monolayer density grown onto the surface of composite substrates was considered as an indicator of the material biocompatibility after 96 h of incubation. Regardless of the superparamagnetic or diamagnetic nature of nanoparticles, the increase in their concentration in the PAAm composite provided a parallel increase in the cell culture proliferation when grown onto the surface of composite substrates. The effects of cell interaction with the nanostructured surface of composites are discussed in order to explain the results. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.|
FE2O3 AND AL2O3 NANOPARTICLES
|metadata.dc.description.sponsorship:||The Russian Scientific Foundation (grant 18-19-00090) supported the experimental parts of this study, including the design, performance, and analysis of experiments.|
|RSCF project card:||18-19-00090|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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