Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102908
Title: Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties
Authors: Shestakova, T. S.
Deev, S. L.
Khalymbadzha, I. А.
Rusinov, V. L.
Paramonov, A. S.
Arseniev, A. S.
Shenkarev, Z. O.
Charushin, V. N.
Chupakhin, O. N.
Issue Date: 2021
Publisher: Springer
Citation: Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties / T. S. Shestakova, S. L. Deev, I. А. Khalymbadzha, et al. — DOI 10.1007/s10593-021-02927-1 // Chemistry of Heterocyclic Compounds. — 2021. — Vol. 57. — Iss. 4. — P. 479-482.
Abstract: [Figure not available: see fulltext.] Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: ANTIVIRAL ACTIVITY
AZOLOAZINES
NMR SPECTROSCOPY
SPIN-SPIN COUPLING CONSTANTS
STABLE ISOTOPES
URI: http://hdl.handle.net/10995/102908
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85105919980
PURE ID: 22099885
eeb997a2-eeae-4cc0-ab3b-317a010a2f7a
ISSN: 93122
DOI: 10.1007/s10593-021-02927-1
metadata.dc.description.sponsorship: This work was supported by the Russian Foundation for Basic Research (grant 20-03-00842) and the Ministry of Science and Higher Education of the Russian Federation (project No. FEUZ-2020-0058 (N687.42B.223/20)).
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