Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102308
Title: Improving treatment of neurodevelopmental disorders: Recommendations based on preclinical studies
Authors: Homberg, J. R.
Kyzar, E. J.
Stewart, A. M.
Nguyen, M.
Poudel, M. K.
Echevarria, D. J.
Collier, A. D.
Gaikwad, S.
Klimenko, V. M.
Norton, W.
Pittman, J.
Nakamura, S.
Koshiba, M.
Yamanouchi, H.
Apryatin, S. A.
Scattoni, M. L.
Diamond, D. M.
Ullmann, J. F. P.
Parker, M. O.
Brown, R. E.
Song, C.
Kalueff, A. V.
Issue Date: 2016
Publisher: Taylor and Francis Ltd
Citation: Improving treatment of neurodevelopmental disorders: Recommendations based on preclinical studies / J. R. Homberg, E. J. Kyzar, A. M. Stewart, et al. — DOI 10.1517/17460441.2016.1115834 // Expert Opinion on Drug Discovery. — 2016. — Vol. 11. — Iss. 1. — P. 11-25.
Abstract: Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.Areas covered: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress in the development of novel medications to treat NDDs. Based on clinical, preclinical and translational models of NDDs, our recommendations cover a wide range of methodological approaches and conceptual strategies.Expert opinion: To improve pharmacotherapy and drug discovery for NDDs, we need a stronger emphasis on targeting multiple endophenotypes, a better dissection of genetic/epigenetic factors or "hidden heritability," and a careful consideration of potential developmental/trophic roles of brain neurotransmitters. The validity of animal NDD models can be improved through discovery of novel (behavioral, physiological and neuroimaging) biomarkers, applying proper environmental enrichment, widening the spectrum of model organisms, targeting developmental trajectories of NDD-related behaviors and comorbid conditions beyond traditional NDDs. While these recommendations cannot be addressed all in once, our increased understanding of NDD pathobiology may trigger innovative cross-disciplinary research expanding beyond traditional methods and concepts. © 2015 2015 Taylor & Francis.
Keywords: ADHD
ANIMAL MODELS
AUTISM
NEURODEVELOPMENTAL DISORDERS
TRANSLATIONAL RESEARCH
AMPHETAMINE PLUS DEXAMPHETAMINE
ARIPIPRAZOLE
ATOMOXETINE
BUSPIRONE
CLONIDINE
HALOPERIDOL
LISDEXAMFETAMINE
METHYLPHENIDATE
NALTREXONE
NEUROTRANSMITTER
OLANZAPINE
PIMOZIDE
RISPERIDONE
SEROTONIN UPTAKE INHIBITOR
ZIPRASIDONE
AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS
BIOLOGICAL MARKER
BEHAVIOR CHANGE
CLINICAL ASSESSMENT
CLINICAL EVALUATION
COMORBIDITY
ENDOPHENOTYPE
ENVIRONMENTAL ENRICHMENT
EPIGENETICS
GENETIC ANALYSIS
GENOTYPE ENVIRONMENT INTERACTION
HEREDITY
HERITABILITY
HUMAN
MENTAL DISEASE
NEUROBIOLOGY
NEUROIMAGING
NONHUMAN
PHENOTYPIC VARIATION
PHYSIOLOGICAL PROCESS
PRIORITY JOURNAL
PRODROMAL SYMPTOM
PSYCHOPHARMACOLOGY
REVIEW
STRATEGIC PLANNING
TRANSLATIONAL RESEARCH
TREATMENT INDICATION
ANIMAL
DISEASE MODEL
DRUG DESIGN
DRUG DEVELOPMENT
GENETICS
METABOLISM
NEURODEVELOPMENTAL DISORDERS
PATHOPHYSIOLOGY
PROCEDURES
ANIMALS
BIOMARKERS
DISEASE MODELS, ANIMAL
DRUG DESIGN
DRUG DISCOVERY
ENDOPHENOTYPES
HUMANS
NEURODEVELOPMENTAL DISORDERS
NEUROTRANSMITTER AGENTS
TRANSLATIONAL MEDICAL RESEARCH
URI: http://hdl.handle.net/10995/102308
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 84955215464
PURE ID: 657641
ee542f12-a043-4bc9-b896-7503aa50791f
ISSN: 17460441
DOI: 10.1517/17460441.2016.1115834
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

Files in This Item:
File Description SizeFormat 
2-s2.0-84955215464.pdf1,14 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.