Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102266
Title: Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
Authors: Homberg, J. R.
Kyzar, E. J.
Nguyen, M.
Norton, W. H.
Pittman, J.
Poudel, M. K.
Gaikwad, S.
Nakamura, S.
Koshiba, M.
Yamanouchi, H.
Scattoni, M. L.
Ullman, J. F. P.
Diamond, D. M.
Kaluyeva, A. A.
Parker, M. O.
Klimenko, V. M.
Apryatin, S. A.
Brown, R. E.
Song, C.
Gainetdinov, R. R.
Gottesman, I. I.
Kalueff, A. V.
Issue Date: 2016
Publisher: Elsevier Ltd
Citation: Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models / J. R. Homberg, E. J. Kyzar, M. Nguyen, et al. — DOI 10.1016/j.neubiorev.2016.03.013 // Neuroscience and Biobehavioral Reviews. — 2016. — Vol. 65. — P. 292-312.
Abstract: Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy. © 2016 Elsevier Ltd.
Keywords: EXPERIMENTAL MODEL
MODEL ORGANISM
NEURODEVELOPMENTAL DISORDER
PRECLINICAL STUDY
TRANSLATIONAL RESEARCH
MONOAMINE DERIVATIVE
OXIDOPAMINE
ANXIETY DISORDER
ATTENTION DEFICIT DISORDER
AUTISM
BEHAVIOR DISORDER
BEHAVIORAL INFLEXIBILITY
BEHAVIORAL RESEARCH
COGNITIVE DEVELOPMENT
COMORBIDITY
COMPULSION
DAT GENE
EMOTION
ENVIRONMENTAL ENRICHMENT
EXPERIMENTAL ANIMAL
EXPERIMENTAL BEHAVIORAL TEST
EXPERIMENTAL TRANSLATIONAL NEUROBEHAVIORAL MODEL
GENE
GENETIC POLYMORPHISM
GENETIC SUSCEPTIBILITY
GENOTYPE ENVIRONMENT INTERACTION
GILLES DE LA TOURETTE SYNDROME
HUMAN
INTEREST RESTRICTION
LEARNING AND MEMORY TEST
MOTOR DYSFUNCTION
NEUROTOXICITY
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PSYCHOLOGICAL MODEL
REVIEW
SEIZURE
SNAP25 GENE
SOCIAL BEHAVIOR
ANIMAL
BRAIN
MENTAL DISEASE
NERVOUS SYSTEM DEVELOPMENT
ANIMALS
AUTISM SPECTRUM DISORDER
AUTISTIC DISORDER
BRAIN
NEURODEVELOPMENTAL DISORDERS
NEUROGENESIS
URI: http://hdl.handle.net/10995/102266
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 84963894206
PURE ID: 786345
544e5c30-74ac-453d-9c48-4a9372d4f462
ISSN: 1497634
DOI: 10.1016/j.neubiorev.2016.03.013
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

Files in This Item:
File Description SizeFormat 
2-s2.0-84963894206.pdf1,06 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.