Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102260
Title: Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications
Authors: Almohammed, S.
Oladapo, S. O.
Ryan, K.
Kholkin, A. L.
Rice, J. H.
Rodriguez, B. J.
Issue Date: 2016
Publisher: Royal Society of Chemistry
Citation: Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications / S. Almohammed, S. O. Oladapo, K. Ryan, et al. — DOI 10.1039/c6ra05732b // RSC Advances. — 2016. — Vol. 6. — Iss. 48. — P. 41809-41815.
Abstract: Self-assembled diphenylalanine (FF) peptide nanotubes (PNTs) have attracted significant attention due to their well-ordered supramolecular structure and wide range of functional capabilities that may enable potential nanobiotechnology applications. However, self-assembled PNTs are generally inhomogeneous at the macroscale, which has limited their potential use. Reproducibly controlling the assembly and alignment of PNTs is therefore critical to enable the widespread use of PNTs, e.g., in sensing applications. In this study, a surface patterning technique based on UV/ozone exposure through a mask is used to align PNTs. Exposed regions become hydrophilic, leading to directed spreading of the FF solution and alignment of the PNTs that improves as the difference in wettability between adjacent regions increases. Alignment was further found to depend on the concentration- and temperature-dependent diameter of the PNTs formed and the size of the hydrophilic area. Finally, aligned PNTs decorated with silver nanoparticles are used to sense an analyte molecule using surface enhanced Raman spectroscopy. © 2016 The Royal Society of Chemistry.
Keywords: HYDROPHILICITY
NANOTUBES
PEPTIDES
RAMAN SPECTROSCOPY
SILVER NANOPARTICLES
WETTING
YARN
BIOSENSING APPLICATIONS
FUNCTIONAL CAPABILITIES
ORDERED SUPRAMOLECULAR STRUCTURE
SENSING APPLICATIONS
SURFACE ENHANCED RAMAN SPECTROSCOPY
SURFACE PATTERNING
TEMPERATURE DEPENDENT
WETTABILITY GRADIENTS
ALIGNMENT
URI: http://hdl.handle.net/10995/102260
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 84966312448
PURE ID: 785458
90c084e3-467a-4368-9c0e-315c1b131b22
ISSN: 20462069
DOI: 10.1039/c6ra05732b
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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